Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0142 | 0.0168 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.4595 | 0.4595 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3384 | 0.3384 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.8455 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4595 | 0.5434 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0142 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1884 | 0.2228 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.4595 | 0.4595 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0142 | 0.0168 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.8455 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4595 | 0.5434 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0142 | 0.0168 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.8455 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0142 | 0.0168 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.3384 | 0.3384 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4595 | 0.5434 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0142 | 0.0168 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.4595 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1884 | 0.1884 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.4595 | 0.4595 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.3384 | 0.3384 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.8455 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0142 | 0.0142 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.8455 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.4595 | 0.4595 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.8455 | 0.8455 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.8455 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0142 | 0.0168 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0142 | 0.0168 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4595 | 0.5434 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.8455 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0142 | 0.0168 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1884 | 0.1884 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.8455 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0142 | 0.0142 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0142 | 0.0168 |
Schistosoma mansoni | kinase | 0.0058 | 0.3629 | 0.4292 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0142 | 0.0142 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.4595 | 0.5434 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.4595 | 0.5434 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.4595 | 0.4595 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.8455 | 0.8455 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.8455 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.8455 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.3384 | 0.3384 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0142 | 0.0142 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.8455 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.4595 | 0.4595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8888 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.