Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.159 | 0.1678 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0057 | 0.0764 | 0.0115 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0103 | 0.159 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0052 | 0.0666 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0052 | 0.0666 | 0.5 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0523 | 0.9197 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0516 | 0.9057 | 1 |
Onchocerca volvulus | CoRest homolog | 0.0539 | 0.9474 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0109 | 0.1688 | 0.1198 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0568 | 1 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0052 | 0.0666 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0052 | 0.0666 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0052 | 0.0666 | 0.4188 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0052 | 0.0666 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0052 | 0.0666 | 0.4188 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0052 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0539 | 0.9474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.9197 | 0.9708 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0052 | 0.0666 | 0.5 |
Echinococcus multilocularis | 0.0052 | 0.0666 | 0.4188 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0052 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.159 | 0.1678 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0052 | 0.0666 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0103 | 0.159 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0052 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0666 | 0.0703 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0052 | 0.0666 | 0.4188 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0052 | 0.0666 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0103 | 0.159 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0052 | 0.0666 | 0.4188 |
Schistosoma mansoni | amine oxidase | 0.0052 | 0.0666 | 0.4188 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1688 | 0.1782 |
Leishmania major | UDP-galactopyranose mutase | 0.0052 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0666 | 0.0703 |
Plasmodium vivax | hypothetical protein, conserved | 0.0052 | 0.0666 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0052 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0764 | 0.0806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.