Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Protein farnesyltransferase | Starlite/ChEMBL | References |
Homo sapiens | Harvey rat sarcoma viral oncogene homolog | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-18 | Harvey rat sarcoma viral oncogene homolog | 189 aa | 177 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Prenyltransferase | 0.0067 | 0.7363 | 0.5 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0067 | 0.7363 | 1 |
Entamoeba histolytica | Ras family GTPase | 0.0069 | 0.7974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.7974 | 1 |
Trichomonas vaginalis | rap1 and, putative | 0.0069 | 0.7974 | 1 |
Trichomonas vaginalis | rheb, putative | 0.0069 | 0.7974 | 1 |
Brugia malayi | Ras protein let-60 | 0.0069 | 0.7974 | 1 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0067 | 0.7363 | 0.5 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0067 | 0.7363 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0067 | 0.7363 | 0.5 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0074 | 1 | 1 |
Trypanosoma brucei | lanosterol synthase | 0.0074 | 1 | 1 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0069 | 0.7974 | 1 |
Echinococcus multilocularis | ras gtpase | 0.0069 | 0.7974 | 1 |
Trichomonas vaginalis | dexras1, putative | 0.0069 | 0.7974 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.0067 | 0.7363 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0074 | 1 | 1 |
Trichomonas vaginalis | ral, putative | 0.0069 | 0.7974 | 1 |
Echinococcus granulosus | ras gtpase | 0.0069 | 0.7974 | 1 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0069 | 0.7974 | 1 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0069 | 0.7974 | 1 |
Entamoeba histolytica | Ras family GTPase | 0.0069 | 0.7974 | 1 |
Entamoeba histolytica | ras-1, putative | 0.0069 | 0.7974 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0069 | 0.7974 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.017 uM | In vitro inhibition of rat farnesyltransferase. | ChEMBL. | 9341905 |
IC50 (binding) | = 0.017 uM | In vitro inhibition of rat farnesyltransferase. | ChEMBL. | 9341905 |
IC50 (functional) | = 0.33 uM | Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells . | ChEMBL. | 9341905 |
IC50 (functional) | = 0.33 uM | Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells . | ChEMBL. | 9341905 |
MED (functional) | = 0.2 uM | Minimum effective dose required to detect unfarnesylated Ras in H-Ras-transformed NIH3T3 (H-Ras-F) cells injected into mice. | ChEMBL. | 9341905 |
MED (functional) | = 0.2 uM | Minimum effective dose required to detect unfarnesylated Ras in H-Ras-transformed NIH3T3 (H-Ras-F) cells injected into mice. | ChEMBL. | 9341905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.