Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | myeloid cell leukemia 1 | Starlite/ChEMBL | No references |
Homo sapiens | RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Giardia lamblia | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative | RecQ helicase-like | 649 aa | 521 aa | 19.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0053 | 0.000000001124 |
Schistosoma mansoni | hypothetical protein | 0.01 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.1382 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1382 | 0.1336 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0053 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0024 | 0.1382 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.01 | 1 | 1 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.01 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0012 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.1382 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.1382 | 0.5 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0053 | 0.0381 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.1382 | 0.5 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.01 | 1 | 1 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.01 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0053 | 0.0381 |
Schistosoma mansoni | DNA helicase recq1 | 0.0024 | 0.1382 | 0.1382 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.1382 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 0.1382 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 1 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.01 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 0.1382 | 0.5 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.01 | 1 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0024 | 0.1382 | 0.1336 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.1382 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.01 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0024 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.01 | 1 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0024 | 0.1382 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0053 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.1382 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.1382 | 0.1336 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.1382 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.373649871 um | PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.