Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0144 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1957 | 0.7362 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0144 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0144 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1246 | 0.4688 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0173 | 0.0651 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1957 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1957 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0144 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1957 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0144 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1246 | 0.4688 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.117 | 0.4403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0144 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0265 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0254 | 0.0453 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0034 | 0.0127 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.117 | 0.0945 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0144 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.117 | 0.094 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.2357 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0144 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1957 | 0.1747 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0254 | 0.0453 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.117 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1957 | 0.1752 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1957 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.1246 | 0.6015 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.1246 | 0.6015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0144 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0144 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1957 | 0.7362 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1957 | 0.7362 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.2658 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.