Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2666 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2666 | 0.2666 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0643 | 0.0643 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2666 | 0.2666 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1733 | 0.6501 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2666 | 0.2666 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1449 | 0.5435 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1449 | 0.1449 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1449 | 0.5435 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2666 | 0.2666 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2666 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1449 | 0.1449 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2666 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1449 | 0.1449 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1733 | 0.6501 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1733 | 0.6501 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1449 | 0.1449 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2666 | 0.2666 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0643 | 0.241 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1733 | 0.6501 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2666 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1449 | 0.1449 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0643 | 0.241 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2666 | 0.2666 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.003 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1449 | 0.1449 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2666 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2666 | 0.2666 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1449 | 0.1449 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0058 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.