Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Beta-glucuronidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | glycosyl hydrolase family 2 | Get druggable targets OG5_131767 | All targets in OG5_131767 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131767 | All targets in OG5_131767 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | Get druggable targets OG5_131767 | All targets in OG5_131767 |
Loa Loa (eye worm) | beta-glucuronidase | Get druggable targets OG5_131767 | All targets in OG5_131767 |
Brugia malayi | Beta-glucuronidase precursor | Get druggable targets OG5_131767 | All targets in OG5_131767 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3991 | 0.4221 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0145 | 0.3991 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0145 | 0.3991 | 0.4221 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0145 | 0.3991 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0047 | 0.0108 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.001 | 0.0011 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.3991 | 0.4221 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3991 | 1 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0283 | 0.9456 | 1 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0275 | 0.9139 | 0.9664 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0296 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0145 | 0.3991 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.5331 | 0.5638 |
Onchocerca volvulus | 0.0145 | 0.3991 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0296 | 1 | 1 |
Onchocerca volvulus | 0.0055 | 0.0423 | 0.106 | |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.2385 | 0.5974 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0145 | 0.3991 | 0.5 |
Brugia malayi | manba-prov protein | 0.0096 | 0.2067 | 0.2186 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0283 | 0.9456 | 1 |
Entamoeba histolytica | beta-galactosidase, putative | 0.02 | 0.6192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0423 | 0.0448 |
Brugia malayi | Beta-glucuronidase precursor | 0.0275 | 0.9139 | 0.9664 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0145 | 0.3991 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0145 | 0.3991 | 0.4221 |
Brugia malayi | Muscle positioning protein 4 | 0.0055 | 0.0423 | 0.0448 |
Leishmania major | hypothetical protein, conserved | 0.0145 | 0.3991 | 0.5 |
Schistosoma mansoni | beta-mannosidase | 0.0096 | 0.2067 | 0.5179 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0145 | 0.3991 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.8 uM | Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry | ChEMBL. | 24602903 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.