Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Mus musculus | fibroblast activation protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.4241 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.051 | 0.0784 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.051 | 0.0784 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.6507 | 0.632 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.6507 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2500 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 7200 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2.5 uM | Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometry | ChEMBL. | 24617858 |
IC50 (binding) | = 7.2 uM | Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometry | ChEMBL. | 24617858 |
IC50 (binding) | > 100 uM | Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometry | ChEMBL. | 24617858 |
IC50 (binding) | > 100 uM | Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometry | ChEMBL. | 24617858 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.