Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta2 | Starlite/ChEMBL | References |
Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta4 | Starlite/ChEMBL | References |
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0176 | 0.0629 | 0.0629 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0176 | 0.0629 | 0.2728 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0629 | 0.2728 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0176 | 0.0629 | 0.0629 |
Schistosoma mansoni | inositol transporter | 0.1892 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.1892 | 1 | 1 |
Brugia malayi | GH02984p | 0.0483 | 0.2307 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0483 | 0.2307 | 0.2307 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0176 | 0.0629 | 0.0629 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0176 | 0.0629 | 0.0629 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.2307 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0483 | 0.2307 | 0.2307 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.1892 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0176 | 0.0629 | 0.2728 |
Echinococcus multilocularis | solute carrier family 5 | 0.1892 | 1 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0483 | 0.2307 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0176 | 0.0629 | 0.0629 |
Brugia malayi | Sodium:solute symporter family protein | 0.0483 | 0.2307 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.0483 | 0.2307 | 0.2307 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0483 | 0.2307 | 0.2307 |
Onchocerca volvulus | 0.0483 | 0.2307 | 1 | |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0483 | 0.2307 | 0.2307 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0629 | 0.2728 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.2307 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0176 | 0.0629 | 0.0629 |
Schistosoma mansoni | inositol transporter | 0.1892 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.1892 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.1892 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0483 | 0.2307 | 0.2307 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.1892 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 397 nM | Antagonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells assessed as inhibition of epibatadine-induced effect after 30 mins by fluorescent membrane potential assay | ChEMBL. | 24649848 |
IC50 (binding) | > 10000 nM | Antagonist activity at rat alpha3beta2 nAChR expressed in HEK293 cells assessed as inhibition of epibatadine-induced effect after 30 mins by fluorescent membrane potential assay | ChEMBL. | 24649848 |
IC50 (binding) | > 10000 nM | Antagonist activity at rat alpha4beta2 nAChR expressed in HEK293 cells assessed as inhibition of epibatadine-induced effect after 30 mins by fluorescent membrane potential assay | ChEMBL. | 24649848 |
Inhibition (binding) | = 106.6 % | Antagonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells assessed as inhibition of epibatadine-induced effect at 10 uM after 30 mins by fluorescent membrane potential assay relative to mecamylamine | ChEMBL. | 24649848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.