Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0789 | 0.0562 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0789 | 0.0562 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0789 | 0.0562 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.4639 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.024 | 0.024 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.5032 | 0.491 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.024 | 0.024 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.5032 | 0.491 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0789 | 0.0562 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.4639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.4243 | 0.4102 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.024 | 0.024 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0789 | 0.0562 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.5032 | 0.491 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.024 | 0.024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0789 | 0.0789 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.5581 | 0.5581 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.5032 | 0.491 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.024 | 0.024 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0789 | 0.0562 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.5581 | 0.5581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0789 | 0.0789 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.024 | 0.024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.