Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase | 0.033 | 0.499 | 0.4957 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.499 | 0.4957 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.499 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.0708 | 0.0708 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.0708 | 0.1419 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.499 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.0708 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0708 | 0.1307 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.0708 | 0.0648 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.0708 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0708 | 0.1307 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.0708 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.0065 | 0.0065 |
Schistosoma mansoni | glutaminase | 0.033 | 0.499 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.499 | 0.499 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.0708 | 0.1419 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0127 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0127 | 0.0127 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.0708 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0618 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.