Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | EYA transcriptional coactivator and phosphatase 2 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | eyes absent homolog | Get druggable targets OG5_129664 | All targets in OG5_129664 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129664 | All targets in OG5_129664 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129664 | All targets in OG5_129664 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_129664 | All targets in OG5_129664 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Schistosoma japonicum | ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative | Get druggable targets OG5_129664 | All targets in OG5_129664 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0043 | 0.0793 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.2427 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0793 | 0.2427 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0793 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0793 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0793 | 0.2427 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0793 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.2427 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0106 | 0.3266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.2427 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0793 | 0.2427 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0793 | 0.0793 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0793 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0793 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0793 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0793 | 0.0793 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0793 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0793 | 0.2427 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0793 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0793 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0793 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.2427 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0793 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0793 | 0.2427 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0793 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0793 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.2427 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0793 | 0.0793 |
Schistosoma mansoni | eyes absent homolog | 0.0106 | 0.3266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.2427 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3266 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0793 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0793 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0793 | 0.2427 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0793 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0793 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0793 | 0.5 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0793 | 0.2427 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0793 | 0.2427 |
Onchocerca volvulus | 0.0043 | 0.0793 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.