Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fucosidase, alpha-L- 1, tissue | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | fucosidase alpha L 1 tissue | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Loa Loa (eye worm) | alpha-L-fucosidase | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Schistosoma mansoni | alpha-l-fucosidase | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Mycobacterium ulcerans | alpha-L-fucosidase | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Schistosoma japonicum | ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Brugia malayi | Alpha-L-fucosidase family protein | Get druggable targets OG5_129683 | All targets in OG5_129683 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0203 | 0.1157 | 0.5 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0313 | 0.4242 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0313 | 0.4242 | 0.5 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0517 | 1 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0313 | 0.4242 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans | ChEMBL. | 9873733 |
IC50 (binding) | = 4 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans | ChEMBL. | 9873733 |
IC50 (binding) | = 11 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
IC50 (binding) | = 11 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
IC50 (binding) | = 11 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
IC50 (binding) | = 11 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
Ki (binding) | = 1.5 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1 | ChEMBL. | 9873733 |
Ki (binding) | = 1.5 nM | Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1 | ChEMBL. | 9873733 |
Ki (binding) | = 8 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
Ki (binding) | = 8 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis | ChEMBL. | 9873733 |
Ki (binding) | = 11 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
Ki (binding) | = 11 nM | Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney | ChEMBL. | 9873733 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.