Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | transporter, putative | 0.0122 | 0 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0122 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0718 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0122 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0122 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 1 | 1 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0122 | 0 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0122 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0718 | 1 | 1 |
Onchocerca volvulus | 0.0718 | 1 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0122 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0718 | 1 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0122 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0122 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0718 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0122 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.5422 | 0.5422 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 17 mg kg-1 | Antitumor activity against mouse L1210 cells allografted in ip dosed BDF1 mouse assessed as increase of life span of host measured up to 45 days | ChEMBL. | 836500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.