Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0235 | 0.7525 | 0.7525 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.0468 | 0.095 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1472 | 0.2986 |
Leishmania major | cathepsin L-like protease | 0.0082 | 0.1472 | 0.0698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0082 | 0.1472 | 0.2986 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0065 | 0.0831 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0082 | 0.1472 | 0.1472 |
Loa Loa (eye worm) | cysteine protease | 0.0082 | 0.1472 | 0.2249 |
Onchocerca volvulus | Cathepsin L homolog | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0065 | 0.0831 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0298 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0082 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1472 | 0.2986 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0082 | 0.1472 | 0.2986 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0169 | 0.4929 | 1 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0082 | 0.1472 | 0.2986 |
Leishmania major | cathepsin L-like protease | 0.0082 | 0.1472 | 0.0698 |
Toxoplasma gondii | cathepsin CPL | 0.0082 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0169 | 0.4929 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0065 | 0.0831 | 0.0831 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0169 | 0.4929 | 1 |
Leishmania major | cathepsin L-like protease | 0.0298 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0082 | 0.1472 | 0.2986 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0298 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0082 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1472 | 0.2986 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0056 | 0.0468 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1472 | 0.2249 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0169 | 0.4929 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0056 | 0.0468 | 0.095 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin b | 0.0169 | 0.4929 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0082 | 0.1472 | 0.2986 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0082 | 0.1472 | 0.2986 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0169 | 0.4929 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.0468 | 0.095 |
Echinococcus multilocularis | cysteine protease | 0.0082 | 0.1472 | 0.2986 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0298 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0298 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Plasmodium vivax | vivapain-2 | 0.0082 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.4929 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0082 | 0.1472 | 0.2249 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0056 | 0.0468 | 0.095 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0065 | 0.0831 | 0.1687 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0272 | 0.8997 | 0.8997 |
Onchocerca volvulus | Cathepsin L homolog | 0.0082 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0082 | 0.1472 | 0.0698 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0056 | 0.0468 | 0.3182 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0169 | 0.4929 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1472 | 0.2986 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0082 | 0.1472 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0065 | 0.0831 | 0.0814 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0082 | 0.1472 | 0.2986 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0082 | 0.1472 | 0.2986 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0065 | 0.0831 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0298 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0082 | 0.1472 | 0.2249 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0082 | 0.1472 | 0.2249 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0082 | 0.1472 | 0.0698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin b | 0.0169 | 0.4929 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0056 | 0.0468 | 0.095 |
Plasmodium vivax | vivapain-2 | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0082 | 0.1472 | 0.0698 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1472 | 0.2986 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.0468 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0169 | 0.4929 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0169 | 0.4929 | 0.4929 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0082 | 0.1472 | 0.2986 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.0468 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0082 | 0.1472 | 0.0698 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0065 | 0.0831 | 0.565 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0298 | 1 | 1 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0082 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0082 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0082 | 0.1472 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0082 | 0.1472 | 0.2249 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0082 | 0.1472 | 0.2986 |
Onchocerca volvulus | 0.0082 | 0.1472 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1472 | 0.2986 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0082 | 0.1472 | 0.2986 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0065 | 0.0831 | 0.0831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 2.7 uM | Growth inhibition of human CCRF-CEM cells after 48 hrs by cell culture assay | ChEMBL. | 264567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.