Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0079 | 0.2924 | 0.2198 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0079 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0079 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0064 | 0.1716 | 0.1716 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0064 | 0.1716 | 0.5868 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.2924 | 0.2924 |
Toxoplasma gondii | cathepsin CPL | 0.0079 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.2924 | 0.2924 |
Brugia malayi | cathepsin L-like precursor | 0.0054 | 0.093 | 0.093 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.093 | 0.093 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.093 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.2924 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0079 | 0.2924 | 0.2924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0054 | 0.093 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.0064 | 0.1716 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.2924 | 0.2924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0079 | 0.2924 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0079 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2924 | 0.2198 |
Echinococcus granulosus | cathepsin l1 | 0.0054 | 0.093 | 0.093 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0079 | 0.2924 | 0.2198 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.093 | 0.093 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0054 | 0.093 | 0.093 |
Entamoeba histolytica | cysteine protease, putative | 0.0079 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0079 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0079 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0054 | 0.093 | 0.093 |
Giardia lamblia | Cathepsin B precursor | 0.0064 | 0.1716 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0079 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0079 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.093 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0079 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.2924 | 0.2924 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0079 | 0.2924 | 0.2924 |
Echinococcus multilocularis | cysteine protease | 0.0079 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | cathepsin B | 0.0064 | 0.1716 | 0.0866 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0054 | 0.093 | 0.093 |
Echinococcus granulosus | cathepsin l1 | 0.0079 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0064 | 0.1716 | 0.1716 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Onchocerca volvulus | 0.0079 | 0.2924 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0079 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0079 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0079 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0079 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0064 | 0.1716 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0079 | 0.2924 | 0.2198 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0064 | 0.1716 | 0.5868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0079 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0079 | 0.2924 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | CNS activity in mouse assessed as alteration of exploratory behaviour at 20 mg/kg, po | ChEMBL. | 833820 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.