Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cysteine protease | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.1329 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.1329 | 0.1329 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.4176 | 0.4176 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.011 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.011 | 0.4176 | 0.4176 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.4176 | 0.4176 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0072 | 0.1126 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.011 | 0.4176 | 0.3437 |
Brugia malayi | cathepsin L-like precursor | 0.0075 | 0.1329 | 0.1329 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Plasmodium vivax | vivapain-2 | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4176 | 0.3437 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0075 | 0.1329 | 0.1329 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0072 | 0.1126 | 0.1126 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.011 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.011 | 0.4176 | 0.4176 |
Leishmania major | cysteine peptidase A (CPA) | 0.011 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0072 | 0.1126 | 0.1126 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.011 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.018 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.018 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.018 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin b | 0.018 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.4176 | 0.4176 |
Echinococcus granulosus | cathepsin b | 0.018 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.018 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.018 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0075 | 0.1329 | 0.1329 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Echinococcus multilocularis | cysteine protease | 0.011 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin b | 0.018 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0075 | 0.1329 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1329 | 0.0228 |
Toxoplasma gondii | cathepsin CPL | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.011 | 0.4176 | 0.3437 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1329 | 0.0228 |
Giardia lamblia | Cathepsin B precursor | 0.0072 | 0.1126 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.011 | 0.4176 | 1 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.011 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.011 | 0.4176 | 1 |
Plasmodium vivax | vivapain-2 | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.011 | 0.4176 | 0.3437 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.011 | 0.4176 | 0.4176 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.011 | 0.4176 | 0.4176 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Echinococcus granulosus | cathepsin b | 0.018 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0075 | 0.1329 | 0.1329 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.011 | 0.4176 | 0.3437 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.1329 | 0.1329 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.011 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.011 | 0.4176 | 0.4176 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0072 | 0.1126 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0072 | 0.1126 | 0.2697 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0072 | 0.1126 | 0.2697 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1329 | 0.0228 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.011 | 0.4176 | 1 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.011 | 0.4176 | 0.4176 |
Onchocerca volvulus | Cathepsin F homolog | 0.011 | 0.4176 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.011 | 0.4176 | 0.4176 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.4176 | 0.4176 |
Echinococcus granulosus | cathepsin l1 | 0.011 | 0.4176 | 0.4176 |
Loa Loa (eye worm) | cysteine protease | 0.011 | 0.4176 | 0.3437 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.4176 | 1 |
Onchocerca volvulus | 0.011 | 0.4176 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.011 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0075 | 0.1329 | 0.1329 |
Leishmania major | cathepsin L-like protease | 0.011 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.011 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.011 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.1329 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 28.2 % | Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity at 5 uM in presence of 10 uM [3H]choline by [3H]choline uptake assay | ChEMBL. | 25801932 |
Activity (binding) | = 59.7 % | Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity at 5 uM in presence of 100 nM [3H]choline by [3H]choline uptake assay | ChEMBL. | 25801932 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.