TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 219.204 | Formula: C10H12F3NO
H donors: 2 H acceptors: 1 LogP: 1.45 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H](c1ccc(cc1)C(F)(F)F)[C@@H](N)C
InChi: 1S/C10H12F3NO/c1-6(14)9(15)7-2-4-8(5-3-7)10(11,12)13/h2-6,9,15H,14H2,1H3/t6-,9+/m0/s1
InChiKey: ZLZXLGAAIQXPKW-IMTBSYHQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	neuropeptide F-like receptor	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.00393165	0.0190499	0.0596406
Schistosoma mansoni	neuropeptide receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	neuropeptide f receptor 76f	0.00202664	0.00243164	0.00150799
Toxoplasma gondii	aminopeptidase n, putative	0.00717575	0.0473497	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.00202664	0.00243164	0.00624091
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.00202664	0.00243164	0.0051958
Brugia malayi	putative neuropeptide receptor	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	neuropeptides capa receptor	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	neuropeptide receptor A26	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Schistosoma mansoni	biogenic amine receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	7TM GPCR rhodopsin	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00717575	0.0473497	0.150576
Echinococcus granulosus	G protein coupled receptor 139	0.00202664	0.00243164	0.00243164
Brugia malayi	Kelch motif family protein	0.00393165	0.0190499	0.0496532
Echinococcus granulosus	dro:myosuppressin receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	TATA binding protein associated factor	0.00717575	0.0473497	0.150576
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	g protein coupled receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	G protein-coupled receptor F59B2.13	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.00199887	0.00218945	0.00218945
Echinococcus granulosus	allatostatin A receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.00199887	0.00218945	0.00218945
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.00717575	0.0473497	0.281186
Schistosoma mansoni	histamine h1 receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	neuropeptide s receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	neuropeptide receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	amine GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Echinococcus granulosus	neuropeptides capa receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	serotonin receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	SRC-1	0.00199887	0.00218945	0.00454789
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00199887	0.00218945	0.00218945
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.00717575	0.0473497	0.5
Brugia malayi	hypothetical protein	0.0204097	0.162795	0.434202
Schistosoma mansoni	amine GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	neuropeptide F receptor	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	tyrosine protein kinase Lyn	0.00199887	0.00218945	0.00218945
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0204097	0.162795	1
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0204097	0.162795	1
Echinococcus granulosus	g-protein coupled receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.00202664	0.00243164	0.00624091
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0204097	0.162795	1
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	integrin beta 2	0.0194749	0.15464	0.15464
Echinococcus multilocularis	fmrfamide receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	hypothetical protein	0.00202664	0.00243164	0.00150799
Onchocerca volvulus		0.0204097	0.162795	0.431247
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	neuropeptide FF receptor 2	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00180399	0.000489437	0.000489437
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	neuropeptide Y receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	dro:myosuppressin receptor	0.00202664	0.00243164	0.00243164
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0204097	0.162795	1
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	GnHR receptor homolog	0.00202664	0.00243164	0.0051958
Echinococcus granulosus	fmrfamide receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.0242446	0.196249	0.629037
Echinococcus multilocularis	neuropeptide receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	Peptidase family M1 containing protein	0.0204097	0.162795	0.434202
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	integrin beta-2	0.0261818	0.213148	0.683338
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	orexin receptor type 2	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.00199887	0.00218945	0.00218945
Echinococcus multilocularis	neuropeptide receptor A26	0.00202664	0.00243164	0.00243164
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.00717575	0.0473497	0.5
Echinococcus granulosus	tyrosine kinase	0.00180399	0.000489437	0.000489437
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0204097	0.162795	0.162795
Echinococcus granulosus	hypothetical protein	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	myosin xvIII	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Schistosoma mansoni	growth hormone secretagogue receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	tyrosine protein kinase Blk	0.00180399	0.000489437	0.000489437
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	g protein coupled receptor	0.00202664	0.00243164	0.00243164
Toxoplasma gondii	aminopeptidase N, putative	0.00717575	0.0473497	0.5
Brugia malayi	Serotonin receptor	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	neuropeptide receptor	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	neuropeptides capa receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	RE15519p	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	biogenic amine receptor	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	neuropeptide receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	opsin-like receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	tm gpcr rhodopsin	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	serotonin receptor	0.00202664	0.00243164	0.00243164
Toxoplasma gondii	aminopeptidase N protein	0.00717575	0.0473497	0.5
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.00717575	0.0473497	0.0473497
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	neuropeptide receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	adenoreceptor	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.013234	0.100198	0.320395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	tyrosine protein kinase Src42A	0.00199887	0.00218945	0.00218945
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00202664	0.00243164	0.00243164
Brugia malayi	G-protein coupled receptor	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	g protein coupled receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	G protein coupled receptor 139	0.00202664	0.00243164	0.00243164
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	putative neuropeptide receptor NPR1	0.00202664	0.00243164	0.0051958
Brugia malayi	Peptidase family M1 containing protein	0.00717575	0.0473497	0.125361
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00717575	0.0473497	0.150576
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00199887	0.00218945	0.00218945
Schistosoma mansoni	opsin-like receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	alpha 1A adrenergic receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.00199887	0.00218945	0.00218945
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Echinococcus granulosus	neuropeptide Y receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	neuropeptide F receptor	0.00202664	0.00243164	0.0051958
Echinococcus granulosus	tm gpcr rhodopsin	0.116382	1	1
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	peptide allatostatin:somatostatin	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.013234	0.100198	0.320395
Onchocerca volvulus		0.00717575	0.0473497	0.120793
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Brugia malayi	ORL1-like opioid receptor	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	amine GPCR	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	integrin beta 2	0.0194749	0.15464	0.15464
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Brugia malayi	AKH receptor	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.00199887	0.00218945	0.00218945
Loa Loa (eye worm)	hypothetical protein	0.00393165	0.0190499	0.0596406
Loa Loa (eye worm)	hypothetical protein	0.00717575	0.0473497	0.150576
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	neuropeptide Y receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.00202664	0.00243164	0.00243164
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0204097	0.162795	1
Brugia malayi	Dopamine receptor protein 1	0.00202664	0.00243164	0.0051958
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	amine GPCR	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.00717575	0.0473497	0.0473497
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	hypothetical protein	0.0374786	0.311695	1
Schistosoma mansoni	neuropeptide F-like receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0204097	0.162795	1
Schistosoma mansoni	opsin-like receptor	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	neuropeptide Y receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0204097	0.162795	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.00199887	0.00218945	0.00218945
Echinococcus multilocularis	neuropeptide receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	orexin receptor type 2	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	serotonin receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.00717575	0.0473497	0.281186
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Echinococcus multilocularis	tyrosine protein kinase Blk	0.00180399	0.000489437	0.000489437
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	hypothetical protein	0.00393165	0.0190499	0.0496532
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.00199887	0.00218945	0.00218945
Schistosoma mansoni	hypothetical protein	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	tachykinin peptides receptor 99D	0.00202664	0.00243164	0.00243164
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	neuropeptides capa receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	tyrosine protein kinase Srms	0.00180399	0.000489437	0.000489437
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	neuropeptide F receptor	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	melatonin receptor type 1A	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	SRC-1	0.00199887	0.00218945	0.00546267
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	hypothetical protein	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Trypanosoma brucei	Aminopeptidase M1, putative	0.0204097	0.162795	1
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	leukotriene A 4 hydrolase	0.00717575	0.0473497	0.0473497
Schistosoma mansoni	biogenic amine receptor	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus multilocularis	neuropeptide s receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	7tm_1 domain containing protein	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	alpha-1 adrenergic receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00199887	0.00218945	0.00218945
Brugia malayi	G protein-coupled receptor	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	G-protein coupled receptor	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Loa Loa (eye worm)	TYRA-2 protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00199887	0.00218945	0.00218945
Echinococcus granulosus	g protein coupled receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	follicle stimulating hormone receptor	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	amine GPCR	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	g protein coupled receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	G-protein coupled receptor, putative	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	allatostatin A receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	biogenic amine 5HT receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00199887	0.00218945	0.00218945
Echinococcus multilocularis	somatostatin receptor	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	Integrin beta pat-3 precursor	0.0261818	0.213148	0.568906
Brugia malayi	larval opioid receptor	0.00202664	0.00243164	0.0051958
Brugia malayi	Tachykinin-like peptides receptor 99D	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	neuropeptide FF receptor 2	0.00202664	0.00243164	0.00243164
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00202664	0.00243164	0.00150799
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Echinococcus granulosus	g protein coupled receptor	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.00199887	0.00218945	0.00218945
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.00202664	0.00243164	0.00150799
Brugia malayi	Peptidase family M1 containing protein	0.0446544	0.374292	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.00202664	0.00243164	0.00243164
Brugia malayi	hypothetical protein	0.00717575	0.0473497	0.125361
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.116382	1	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0314204	0.258846	0.830181
Echinococcus granulosus	biogenic amine 5HT receptor	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.00180399	0.000489437	0.000489437
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.013234	0.100198	0.100198
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Mycobacterium ulcerans	aminopeptidase N PepN	0.0204097	0.162795	1
Echinococcus granulosus	aminopeptidase N	0.0446544	0.374292	0.374292
Trypanosoma brucei	Aminopeptidase M1, putative	0.0204097	0.162795	1
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	sulfakinin receptor protein	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.013234	0.100198	0.610243
Onchocerca volvulus		0.0446544	0.374292	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0204097	0.162795	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00202664	0.00243164	0.00150799
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Echinococcus granulosus	tyrosine protein kinase Src64B	0.00199887	0.00218945	0.00218945
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0204097	0.162795	1
Echinococcus multilocularis	fmrfamide receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.00202664	0.00243164	0.0051958
Echinococcus granulosus	tm gpcr rhodopsin	0.00202664	0.00243164	0.00243164
Trypanosoma cruzi	aminopeptidase, putative	0.0204097	0.162795	1
Echinococcus granulosus	neuropeptide receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	hypothetical protein	0.00202664	0.00243164	0.00624091
Brugia malayi	G-protein coupled receptor	0.00202664	0.00243164	0.0051958
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.00717575	0.0473497	0.150576
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.00717575	0.0473497	0.5
Schistosoma mansoni	aminopeptidase A (M01 family)	0.00717575	0.0473497	0.281186
Brugia malayi	Dopamine receptor protein 2	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	sex peptide receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	Dopamine receptor	0.00202664	0.00243164	0.0051958
Echinococcus multilocularis	aminopeptidase N	0.0446544	0.374292	0.374292
Brugia malayi	Melatonin receptor type 1A	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	hypothetical protein	0.00202664	0.00243164	0.00150799
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00199887	0.00218945	0.00218945
Brugia malayi	Serotonin receptor	0.00202664	0.00243164	0.0051958
Schistosoma mansoni	integrin beta subunit	0.0155432	0.120343	0.735673
Echinococcus multilocularis	g-protein coupled receptor	0.00202664	0.00243164	0.00243164
Loa Loa (eye worm)	aminopeptidase N	0.0204097	0.162795	0.52154
Echinococcus granulosus	sex peptide receptor	0.00202664	0.00243164	0.00243164
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.00717575	0.0473497	0.0473497
Entamoeba histolytica	aminopeptidase, putative	0.0204097	0.162795	0.5
Echinococcus granulosus	somatostatin receptor	0.00202664	0.00243164	0.00243164
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.00717575	0.0473497	0.5
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0204097	0.162795	0.162795
Brugia malayi	hypothetical protein	0.00202664	0.00243164	0.0051958
Loa Loa (eye worm)	G-protein coupled receptor	0.00202664	0.00243164	0.00624091
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.013234	0.100198	0.457778
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00202664	0.00243164	0.00243164
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.00202664	0.00243164	0.00243164
Brugia malayi	TATA binding protein associated factor	0.00717575	0.0473497	0.125361

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 5 uM	Antiplasmodial activity against ring stage Plasmodium falciparum 3D7A infected in erythrocytes incubated for 24 hrs prior to [3H]hypoxanthine incorporation measured after 24 hrs	ChEMBL.	24944739

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	24944739

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3298969

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1899294