Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | peptide allatostatin:somatostatin | G protein-coupled receptor 17 | 367 aa | 306 aa | 21.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.1553 | 0.1699 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0141 | 0.1553 | 0.1699 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0092 | 0.0623 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.6093 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0096 | 0.0698 | 0.0081 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0109 | 0.095 | 0.0544 |
Chlamydia trachomatis | glutamine binding protein | 0.0069 | 0.0183 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.1553 | 0.1699 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0092 | 0.0623 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.191 | 0.1707 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0069 | 0.0183 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0582 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0212 | 0.2913 | 0.4781 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.1553 | 0.1699 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0191 | 0.2519 | 0.3429 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0191 | 0.2519 | 0.3429 |
Echinococcus multilocularis | geminin | 0.0159 | 0.191 | 0.231 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0092 | 0.0623 | 0.5 |
Echinococcus granulosus | geminin | 0.0159 | 0.191 | 0.231 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0109 | 0.095 | 0.0544 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.0686 | 0.0059 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0378 | 0.6093 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0479 | 0.8015 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0136 | 0.1464 | 0.1101 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0378 | 0.6093 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0212 | 0.2913 | 0.4186 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.1553 | 0.1699 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.6093 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0212 | 0.2913 | 0.4186 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.0686 | 0.0059 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0541 | 0.9216 | 1 |
Leishmania major | 0.0378 | 0.6093 | 1 | |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0069 | 0.0183 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0378 | 0.6093 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0378 | 0.6093 | 0.7388 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0378 | 0.6093 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0378 | 0.6093 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0069 | 0.0183 | 0.5 |
Brugia malayi | hypothetical protein | 0.0092 | 0.0623 | 0.1023 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.191 | 0.1707 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0378 | 0.6093 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Bmax (binding) | = 56.6 pmol | Binding affinity to human GPR17 expressed in CHO-K1 cell membranes assessed per mg protein after 60 mins by saturation curve study | ChEMBL. | 24900835 |
Kd (binding) | = 1256 nM | Binding affinity to human GPR17 expressed in CHO-K1 cell membranes after 60 mins by saturation curve study | ChEMBL. | 24900835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.