Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine palmitoyltransferase 1 | 0.0039 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.5784 | 0.5784 |
Trichomonas vaginalis | 2-amino-3-ketobutyrate coenzyme A ligase, putative | 0.0039 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 1 | 1 |
Trichomonas vaginalis | serine palmitoyltransferase, putative | 0.0039 | 1 | 1 |
Echinococcus granulosus | serine palmitoyltransferase long chain base | 0.0039 | 1 | 1 |
Toxoplasma gondii | glycine C-acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | serine-palmitoyl-CoA transferase, putative | 0.0039 | 1 | 1 |
Plasmodium falciparum | serine C-palmitoyltransferase, putative | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | serine palmitoyltransferase, putative | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | serine palmitoyltransferase, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 1 | 1 |
Plasmodium vivax | serine C-palmitoyltransferase, putative | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.5784 | 0.5 | |
Leishmania major | serine palmitoyltransferase-like protein | 0.0039 | 1 | 1 |
Toxoplasma gondii | 8-amino-7-oxononanoate synthase | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | serine-palmitoyl-CoA transferase, putative | 0.0039 | 1 | 1 |
Echinococcus multilocularis | serine palmitoyltransferase subunit | 0.0033 | 0.5784 | 0.5784 |
Echinococcus multilocularis | serine palmitoyltransferase, long chain base | 0.0039 | 1 | 1 |
Giardia lamblia | Serine palmitoyltransferase 1 | 0.0039 | 1 | 1 |
Chlamydia trachomatis | 8-amino-7-oxononanoate synthase | 0.0024 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12 ug ml-1 | Antibacterial activity against Escherichia coli MC/35 assessed as inhibition of visible growth after 24 hrs by serial dilution method | ChEMBL. | 333113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.