Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 6D, cGMP-specific, rod, delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Schistosoma mansoni | retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Schistosoma japonicum | ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Trichomonas vaginalis | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Ras-related protein RAB2B, putative | phosphodiesterase 6D, cGMP-specific, rod, delta | 93 aa | 81 aa | 28.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1201 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0721 | 0.4411 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0721 | 0.4411 | 0.4411 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1201 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1201 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0614 | 0.3162 | 0.3162 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0721 | 0.4411 | 0.5 |
Trichomonas vaginalis | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative | 0.0342 | 0 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0721 | 0.4411 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1201 | 1 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0721 | 0.4411 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0721 | 0.4411 | 0.4411 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 17.4 degrees C | Binding affinity to PDE-delta (unknown origin) assessed as shift in melting temperature | ChEMBL. | 24884780 |
Kd (binding) | = 231 nM | Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay | ChEMBL. | 24884780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.