Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 6D, cGMP-specific, rod, delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Schistosoma japonicum | ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Schistosoma mansoni | retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132370 | All targets in OG5_132370 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Ras-related protein RAB2B, putative | phosphodiesterase 6D, cGMP-specific, rod, delta | 93 aa | 81 aa | 28.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1472 | 0.6615 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1472 | 0.6615 | 0.6615 |
Loa Loa (eye worm) | hypothetical protein | 0.1048 | 0.4131 | 0.4131 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1472 | 0.6615 | 0.5 |
Trichomonas vaginalis | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative | 0.0342 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.205 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1472 | 0.6615 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1472 | 0.6615 | 0.6615 |
Leishmania major | C-8 sterol isomerase-like protein | 0.205 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.205 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.205 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1472 | 0.6615 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to PDE-delta in MDCK cell lysate after 2 hrs by pull down assay | ChEMBL. | 24884780 | |
Inhibition (binding) | Binding affinity to PDE-delta in human PancTuI cells assessed as inhibition of Ras-PDE-delta complex formation after 2 hrs by pull down assay | ChEMBL. | 24884780 | |
Inhibition (binding) | Binding affinity to PDE-delta in human PancTuI cells assessed as inhibition of Ras-PDE-delta complex formation at 500 nM after 2 hrs by pull down assay | ChEMBL. | 24884780 | |
Kd (binding) | = 1.1 nM | Binding affinity to PDE-delta (unknown origin) by time-resolved fluorescence anisotropic analysis | ChEMBL. | 24884780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.