Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.00112312 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.00267279 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus granulosus | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.00121494 | 0.0592477 | 0.0592477 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus multilocularis | tubulin subunit beta | 0.00267279 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.00267279 | 1 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.00267279 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.00112312 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.00267279 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Trichomonas vaginalis | tubulin beta chain, putative | 0.00267279 | 1 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.00267279 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.00267279 | 1 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Brugia malayi | beta-tubulin, identical | 0.00267279 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.00267279 | 1 | 0.5 |
Brugia malayi | Tubulin beta-1 chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Loa Loa (eye worm) | BEN-1 protein | 0.00267279 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.00267279 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.00121494 | 0.0592477 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.00267279 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Giardia lamblia | Beta tubulin | 0.00267279 | 1 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.00267279 | 1 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus granulosus | beta tubulin | 0.00267279 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.00267279 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Echinococcus multilocularis | beta tubulin | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.00267279 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.00267279 | 1 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.00267279 | 1 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.00267279 | 1 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.00267279 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.00267279 | 1 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.00267279 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.21 uM | Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis | ChEMBL. | 24904967 |
IC50 (functional) | = 5.14 uM | Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs | ChEMBL. | 24904967 |
IC50 (ADMET) | > 50 uM | Cytotoxicity against human HepG2 cells after 48 hrs | ChEMBL. | 24904967 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium berghei | ChEMBL23 | 24904967 | |
Plasmodium falciparum | 24904967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.