Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate lyase 1 | Starlite/ChEMBL | References |
Homo sapiens | smoothened, frizzled class receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | sphingosine-1-phosphate lyase 1 | 568 aa | 524 aa | 39.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | frizzled | 0.0018 | 0.0114 | 0.0114 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | frizzled | 0.0018 | 0.0114 | 0.0114 |
Schistosoma mansoni | frizzled | 0.0018 | 0.0114 | 0.0416 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.0122 | 0.2733 | 0.2733 |
Echinococcus multilocularis | smoothened | 0.041 | 1 | 1 |
Schistosoma mansoni | frizzled-like receptor | 0.0018 | 0.0114 | 0.0416 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.0122 | 0.2733 | 0.5 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0018 | 0.0114 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.9786 | 1 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.0122 | 0.2733 | 1 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0122 | 0.2733 | 1 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.0122 | 0.2733 | 1 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.0122 | 0.2733 | 0.2733 |
Echinococcus granulosus | frizzled 5 | 0.0018 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0018 | 0.0114 | 0.0116 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.0122 | 0.2733 | 1 |
Echinococcus granulosus | frizzled 4 | 0.0018 | 0.0114 | 0.0114 |
Leishmania major | sphingosine 1-phosphate lyase | 0.0122 | 0.2733 | 1 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0018 | 0.0114 | 0.0416 |
Echinococcus multilocularis | frizzled 10 | 0.0018 | 0.0114 | 0.0114 |
Echinococcus multilocularis | frizzled 5 | 0.0018 | 0.0114 | 0.0114 |
Echinococcus multilocularis | frizzled 4 | 0.0018 | 0.0114 | 0.0114 |
Echinococcus granulosus | frizzled | 0.0018 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0018 | 0.0114 | 0.0116 |
Schistosoma mansoni | frizzled-like receptor | 0.0018 | 0.0114 | 0.0416 |
Echinococcus multilocularis | frizzled | 0.0018 | 0.0114 | 0.0114 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.0122 | 0.2733 | 1 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | frizzled | 0.0018 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2733 | 0.2793 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.21 uM | Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr | ChEMBL. | 24809814 |
IC50 (binding) | = 0.44 uM | Antagonist activity at smoothened (unknown origin) | ChEMBL. | 24809814 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.