Detailed view for EgrG_000634400

Basic information

TDR Targets ID: 577675
Echinococcus granulosus, sphingosine 1 phosphate lyase 1
Source Database / ID:  GeneDB

pI: 9.1414 | Length (AA): 543 | MW (Da): 59390 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00282   Pyridoxal-dependent decarboxylase conserved domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0016831   carboxy-lyase activity  
GO:0003824   catalytic activity  
GO:0019752   carboxylic acid metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 525 1wyu (B) 2 459 14.00 0.0000072 1 0.923028 1.28
85 536 3mad (A) 59 505 41.00 0 1 1.31141 -0.13
89 510 5k1r (A) 16 465 41.00 0 1 1.26626 -0.39
91 539 4q6r (A) 111 553 49.00 0 1 1.42589 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128248)

Species Accession Gene Product
Arabidopsis thaliana AT1G27980   Sphingosine-1-phosphate lyase
Brugia malayi Bm1_39180   Pyridoxal-dependent decarboxylase conserved domain containing protein
Candida albicans CaO19.14213   similar to dihydrosphingosine phosphate lyase
Candida albicans CaO19.6951   Dihydrosphingosine-1-phosphate lyase
Caenorhabditis elegans CELE_Y66H1B.4   Protein SPL-1
Caenorhabditis elegans CELE_B0222.4   Protein TAG-38
Dictyostelium discoideum DDB_G0280183   S1P lyase
Dictyostelium discoideum DDB_G0282819   S1P lyase
Drosophila melanogaster Dmel_CG8946   Sphingosine-1-phosphate lyase
Echinococcus granulosus EgrG_000634400   sphingosine 1 phosphate lyase 1
Entamoeba histolytica EHI_039350   s phingosine-1-phosphate lyase 1, putative
Echinococcus multilocularis EmuJ_000634400   sphingosine 1 phosphate lyase 1
Homo sapiens ENSG00000166224   sphingosine-1-phosphate lyase 1
Leishmania braziliensis LbrM.30.2300   sphingosine phosphate lyase-like protein, putative
Leishmania donovani LdBPK_302360.1   sphingosine phosphate lyase-like protein, putative
Leishmania infantum LinJ.30.2360   sphingosine 1-phosphate lyase, putative;with=GeneDB:LmjF30.2350
Leishmania major LmjF.30.2350   sphingosine 1-phosphate lyase
Leishmania mexicana LmxM.29.2350   sphingosine phosphate lyase-like protein, putative
Loa Loa (eye worm) LOAG_02025   hypothetical protein
Mus musculus ENSMUSG00000020097   sphingosine phosphate lyase 1
Oryza sativa 4326459   Os01g0100900
Saccharomyces cerevisiae YDR294C   sphinganine-1-phosphate aldolase DPL1
Schistosoma japonicum Sjp_0056830   ko:K01634 sphinganine-1-phosphate aldolase [EC4.1.2.27], putative
Schistosoma japonicum Sjp_0105880   expressed protein
Schistosoma japonicum Sjp_0048430   expressed protein
Schistosoma japonicum Sjp_0048400   hypothetical protein
Schistosoma mansoni Smp_154950   sphingosine phosphate lyase
Schmidtea mediterranea mk4.003718.03   Sphingosine-1-phosphate lyase 1
Trypanosoma brucei gambiense Tbg972.6.3390   sphingosine phosphate lyase-like protein, putative
Trypanosoma brucei Tb927.6.3630   sphingosine 1-phosphate lyase, putative
Trypanosoma congolense TcIL3000_6_3180   sphingosine phosphate lyase-like protein, putative
Trypanosoma cruzi TcCLB.506941.150   sphingosine 1-phosphate lyase, putative
Trypanosoma cruzi TcCLB.511511.150   sphingosine 1-phosphate lyase, putative

Essentiality

EgrG_000634400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.3630 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.3630 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.3630 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.3630 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y66H1B.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus sphingosine phosphate lyase 1 Compounds References
Rattus norvegicus Sphingosine-1-phosphate lyase 1 Compounds References
Homo sapiens sphingosine-1-phosphate lyase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1658 1 1
0.1712 1 1
0.1228 1 1
0.1594 1 1
0.02 1 1
0.1356 1 1
0.1623 1 1
0.1481 1 1
0.09 0.3395 1
0.16 1 1
0.0122 1 1
0.0117 0.2883 0.2883
0.0122 0.5 0.5
0.0106 0.5 0.5
0.0929 1 1
0.0122 0.5 0.5
0.0101 0.5 0.5
0.164 1 1
0.0103 0.5 0.5
0.0832 1 1
0.1607 1 1
0.0122 0.2733 0.2733
0.1763 1 1
0.1712 1 1
0.1741 1 1
0.1712 1 1
0.0122 0.3376 0.6713
0.1384 1 1
0.0875 0.2605 0.5686
0.0106 1 1
0.0875 0.2605 0.5686
0.09 0.3395 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000634400 (Echinococcus granulosus), sphingosine 1 phosphate lyase 1
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