Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | oligopeptidase b | 0.0062 | 0.038 | 0.038 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0062 | 0.038 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0155 | 1 | 1 |
Leishmania major | oligopeptidase b | 0.0062 | 0.038 | 0.038 |
Trypanosoma cruzi | oligopeptidase b | 0.0062 | 0.038 | 0.038 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0062 | 0.038 | 0.038 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0139 | 0.8325 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0155 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0062 | 0.038 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0155 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Trypanosoma brucei | oligopeptidase b | 0.0062 | 0.038 | 0.038 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0062 | 0.038 | 0.038 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0062 | 0.038 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0155 | 1 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0062 | 0.038 | 0.038 |
Trypanosoma brucei | prolyl endopeptidase | 0.0155 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0155 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0155 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0155 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0155 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0062 | 0.038 | 0.038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 204.1 nM | Inhibition of recombinant GST-tagged GSK-3beta (unknown origin) expressed in Escherichia coli strain BL21-Codon Plus (DE3) using Ser/Thr 9 peptide substrate by Z'-LYTE kinase assay | ChEMBL. | 25662701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.