Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0062 | 0.0433 | 0.0433 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0062 | 0.0433 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0062 | 0.0433 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.014 | 0.8334 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0157 | 1 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0062 | 0.0433 | 0.0433 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0157 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0157 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0157 | 1 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0157 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | oligopeptidase b | 0.0062 | 0.0433 | 0.0433 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Leishmania major | oligopeptidase b | 0.0062 | 0.0433 | 0.0433 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0062 | 0.0433 | 0.0433 |
Echinococcus granulosus | prolyl endopeptidase | 0.0157 | 1 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0062 | 0.0433 | 0.0433 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0062 | 0.0433 | 0.0433 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0157 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0157 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0062 | 0.0433 | 0.0433 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Trypanosoma brucei | oligopeptidase b | 0.0062 | 0.0433 | 0.0433 |
Trypanosoma brucei | prolyl endopeptidase | 0.0157 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 74.1 nM | Inhibition of recombinant GST-tagged GSK-3beta (unknown origin) expressed in Escherichia coli strain BL21-Codon Plus (DE3) using Ser/Thr 9 peptide substrate by Z'-LYTE kinase assay | ChEMBL. | 25662701 |
Inhibition (binding) | Inhibition of GSK-3beta in Sprague-Dawley rat primary cerebellar granule neurons assessed as reduction in Tau Ser396 phosphorylation at 10 uM by Western blotting method | ChEMBL. | 25662701 | |
Inhibition (binding) | = 0.5 % | Inhibition of N-terminal His-tagged recombinant JAK2 (unknown origin) at 2 uM by HTRF assay | ChEMBL. | 25662701 |
Inhibition (binding) | = 2.3 % | Inhibition of Drak2 (unknown origin) at 2 uM by ADP-GLO kinase assay | ChEMBL. | 25662701 |
Inhibition (binding) | = 2.5 % | Inhibition of N-terminal His-tagged recombinant PKC-epsilon (unknown origin) at 2 uM by HTRF assay | ChEMBL. | 25662701 |
Inhibition (binding) | = 4.3 % | Inhibition of BRAF (unknown origin) at 2 uM by HTRF assay | ChEMBL. | 25662701 |
Inhibition (binding) | = 11.3 % | Inhibition of N-terminal His-tagged recombinant IKK2 (unknown origin) at 2 uM by HTRF assay | ChEMBL. | 25662701 |
Inhibition (binding) | = 24 % | Inhibition of recombinant N-terminal His-tagged AKT1 (unknown origin) expressed in Escherichia coli strain BL21-Codon Plus (DE3) at 2 uM using Ser/Thr 6 peptide substrate by Z'-LYTE kinase assay | ChEMBL. | 25662701 |
Inhibition (binding) | = 39.8 % | Inhibition of CDK2/CycA2 (unknown origin) at 2 uM using Ser/Thr 12 peptide substrate by Z'-LYTE kinase assay | ChEMBL. | 25662701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.