Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0517 | 0.6803 | 0.6803 |
Brugia malayi | Cathepsin L-like precursor | 0.0208 | 0.0839 | 0.0839 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0301 | 0.2636 | 0.1962 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0301 | 0.2636 | 0.2636 |
Echinococcus multilocularis | cathepsin b | 0.0683 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.2636 | 0.1586 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Leishmania major | cathepsin L-like protease | 0.0517 | 0.6803 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0208 | 0.0839 | 0.3182 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0208 | 0.0839 | 0.0839 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0301 | 0.2636 | 0.2636 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0301 | 0.2636 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Plasmodium vivax | vivapain-2 | 0.0301 | 0.2636 | 1 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0301 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0301 | 0.2636 | 0.2636 |
Giardia lamblia | Cathepsin B precursor | 0.026 | 0.1851 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0301 | 0.2636 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0301 | 0.2636 | 0.1962 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0301 | 0.2636 | 0.2636 |
Echinococcus granulosus | cathepsin b | 0.0683 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0301 | 0.2636 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0208 | 0.0839 | 0.3182 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0517 | 0.6803 | 0.6803 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0208 | 0.0839 | 0.0839 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0683 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0208 | 0.0839 | 0.0839 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0683 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.2636 | 0.2636 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0301 | 0.2636 | 0.2636 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.2636 | 0.2636 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0301 | 0.2636 | 0.2636 |
Leishmania major | cathepsin L-like protease | 0.0517 | 0.6803 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0301 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.026 | 0.1851 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.2636 | 0.1962 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.2636 | 0.2636 |
Plasmodium vivax | vivapain-2 | 0.0301 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.026 | 0.1851 | 0.1851 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0424 | 0.5006 | 0.5006 |
Leishmania major | cathepsin L-like protease | 0.0517 | 0.6803 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0301 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0301 | 0.2636 | 0.1962 |
Entamoeba histolytica | cysteine protease, putative | 0.0301 | 0.2636 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.026 | 0.1851 | 0.1105 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0683 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0517 | 0.6803 | 0.6803 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.2636 | 0.2636 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0517 | 0.6803 | 0.6803 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Echinococcus granulosus | cathepsin b | 0.0683 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0301 | 0.2636 | 0.2636 |
Brugia malayi | Cathepsin L-like precursor | 0.0208 | 0.0839 | 0.0839 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.2636 | 0.1586 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.2636 | 0.1586 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0301 | 0.2636 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.026 | 0.1851 | 0.1851 |
Leishmania major | cysteine peptidase A (CPA) | 0.0301 | 0.2636 | 0.1586 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.026 | 0.1851 | 0.7022 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0208 | 0.0839 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0301 | 0.2636 | 0.2636 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Onchocerca volvulus | 0.0301 | 0.2636 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0301 | 0.2636 | 0.2636 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0683 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.026 | 0.1851 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0208 | 0.0839 | 0.0839 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0287 | 0.2369 | 0.2369 |
Toxoplasma gondii | cathepsin CPL | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.2636 | 0.2636 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0683 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.2636 | 0.1586 |
Onchocerca volvulus | Cathepsin L homolog | 0.0301 | 0.2636 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.026 | 0.1851 | 0.2721 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0301 | 0.2636 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0301 | 0.2636 | 0.2636 |
Brugia malayi | Cathepsin L-like precursor | 0.0301 | 0.2636 | 0.2636 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0517 | 0.6803 | 1 |
Leishmania major | cathepsin L-like protease | 0.0301 | 0.2636 | 0.1586 |
Echinococcus multilocularis | cathepsin b | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0301 | 0.2636 | 0.1962 |
Loa Loa (eye worm) | fibroinase | 0.0301 | 0.2636 | 0.1962 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0301 | 0.2636 | 0.2636 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 29.7 uM | Inhibition of BRD4 bromodomain-1 (unknown origin) by europium based LANCE TR-FRET assay | ChEMBL. | 25678016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.