Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 1B (muscle) | 738 aa | 617 aa | 28.0 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0376 | 0.119 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0376 | 0.119 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0829 | 1 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0829 | 1 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0376 | 0.119 | 0.5 |
Toxoplasma gondii | cathepsin CPC1 | 0.0829 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0829 | 1 | 0.5 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0829 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0376 | 0.119 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0376 | 0.119 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0785 | 0.9131 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0829 | 1 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0829 | 1 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0785 | 0.9131 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0515 | 0.3886 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1966 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 0.5269 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 4.2611 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.