Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | coagulation factor XI | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Onchocerca volvulus | 0.0346 | 0.9658 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0425 | 0.044 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0169 | 0.3556 | 0.3681 |
Toxoplasma gondii | PAN domain-containing protein | 0.0356 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0425 | 0.044 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0169 | 0.3556 | 0.3391 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.9658 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0346 | 0.9658 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3556 | 0.3391 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0078 | 0.0425 | 1 |
Onchocerca volvulus | 0.0169 | 0.3556 | 0.3391 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0425 | 0.044 |
Brugia malayi | Trypsin family protein | 0.0346 | 0.9658 | 1 |
Onchocerca volvulus | 0.0319 | 0.8721 | 0.8985 | |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.9658 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0346 | 0.9658 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.