Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Loa Loa (eye worm) | ring canal kelch protein | 0 | 0.0003 | 1 |
Echinococcus granulosus | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0 | 0.0003 | 1 |
Echinococcus multilocularis | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3781 | 0.3792 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3781 | 0.3781 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3781 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3781 | 0.3781 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Brugia malayi | BTB/POZ domain containing protein | 0 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0114 | 0.9972 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0114 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 0.9972 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 0.9972 |
Echinococcus granulosus | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Brugia malayi | Kelch-like protein X | 0 | 0.0003 | 0.0007 |
Echinococcus multilocularis | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3781 | 0.3781 |
Loa Loa (eye worm) | Klhl5 protein | 0 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.75 uM | Inhibition of Keap1/Nrf2 complex (unknown origin) | ChEMBL. | 25937010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.