Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | biotin carboxylase | 0.0061 | 0.0261 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0127 | 0.1293 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.0125 | 0.1275 | 0.0952 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0175 | 0.2048 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0169 | 0.1952 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0067 | 0.0357 | 0.1741 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0067 | 0.0357 | 0.1741 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0108 | 0.1007 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0127 | 0.1293 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0175 | 0.2048 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0175 | 0.2048 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0125 | 0.1275 | 0.5429 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0175 | 0.2048 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0175 | 0.2048 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 1 | 1 |
Treponema pallidum | licC protein (licC) | 0.0125 | 0.1275 | 0.5 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0169 | 0.1952 | 0.5 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0175 | 0.2048 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0684 | 1 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0684 | 1 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0175 | 0.2048 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | = 1 uM | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.