TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 211.153 | Formula: C6H14NO5P
H donors: 3 H acceptors: 5 LogP: -1.87 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(CP(=O)(O)O)CC(=O)N(O)C
InChi: 1S/C6H14NO5P/c1-5(4-13(10,11)12)3-6(8)7(2)9/h5,9H,3-4H2,1-2H3,(H2,10,11,12)
InChiKey: ACPXIHKQSXLCRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras		References
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable aminotransferase	0.0022	0.0009	0.0019
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0035	0.0092	0.0815
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0035	0.0092	0.0548
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0193	0.1133	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0092	0.0548
Treponema pallidum	hypothetical protein	0.0031	0.0067	0.0067
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0089	0.0451	0.0451
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0035	0.0092	0.0548
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.0355	0.3135
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0039	0.0122	0.108
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0035	0.0092	0.0548
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0022	0.0009	0.0009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0035	0.0092	0.0548
Loa Loa (eye worm)	glutaminase	0.0276	0.1685	1
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0245	0.1479	0.878
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0056	0.0234	0.0234
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0022	0.0009	0.0009
Onchocerca volvulus	Bile acid receptor homolog	0.0035	0.0092	0.5
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0067	0.0304	0.2687
Echinococcus granulosus	ecdysone induced protein 78C	0.0035	0.0092	0.0815
Trichomonas vaginalis	aldehyde oxidase, putative	0.0189	0.1108	0.6579
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0067	0.0304	0.1807
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0092	0.0815
Treponema pallidum	hypothetical protein	0.0025	0.0031	0.0031
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0022	0.0009	0.0009
Schistosoma mansoni	aldehyde dehydrogenase	0.0193	0.1133	0.6726
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0039	0.0122	0.4019
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0035	0.0092	0.0815
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0092	0.0815
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.0009	0.0079
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0039	0.0122	0.108
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0039	0.0122	0.0114
Toxoplasma gondii	aldehyde dehydrogenase	0.0193	0.1133	0.1133
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0092	0.0815
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+])	0.0039	0.0122	0.0255
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0193	0.1133	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.0355	0.3135
Leishmania major	aldehyde dehydrogenase, putative	0.0039	0.0122	0.108
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0245	0.1479	0.308
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0022	0.0009	0.0053
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0035	0.0092	0.0548
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0035	0.0092	0.0815
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0009	0.0009
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0089	0.0451	0.0451
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0193	0.1133	0.2359
Schistosoma mansoni	coup transcription factor	0.0035	0.0092	0.0548
Echinococcus multilocularis	FTZ F1 alpha	0.0035	0.0092	0.0815
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0067	0.0304	1
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.0009	0.0079
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.075	0.4803	1
Echinococcus granulosus	ornithine aminotransferase	0.0022	0.0009	0.0079
Schistosoma mansoni	thyroid hormone receptor	0.0035	0.0092	0.0548
Brugia malayi	steroid hormone receptor	0.0035	0.0092	0.0548
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0193	0.1133	0.1133
Brugia malayi	Steroid receptor seven-up type 2	0.0035	0.0092	0.0548
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0193	0.1133	0.1133
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0035	0.0092	0.0548
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	0.0039	0.0122	0.0255
Brugia malayi	follicle stimulating hormone receptor	0.0235	0.1413	0.8391
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0035	0.0092	0.0548
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0035	0.0092	0.0548
Echinococcus granulosus	succinate semialdehyde dehydrogenase	0.0039	0.0122	0.108
Plasmodium falciparum	ornithine aminotransferase	0.0022	0.0009	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0035	0.0092	0.0548
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0035	0.0092	0.0815
Mycobacterium ulcerans	NAD-dependent aldehyde dehydrogenase AldA	0.0039	0.0122	0.0122
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0035	0.0092	0.0548
Echinococcus granulosus	FTZ F1 alpha	0.0035	0.0092	0.0815
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0193	0.1133	0.1133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0035	0.0092	0.0548
Schistosoma mansoni	nuclear hormone receptor	0.0035	0.0092	0.0548
Schistosoma mansoni	retinoic acid receptor RXR	0.0143	0.0805	0.4778
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.1539	1	1
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.1539	1	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0067	0.0304	0.1807
Brugia malayi	photoreceptor-specific nuclear receptor	0.0035	0.0092	0.0548
Brugia malayi	glutaminase DH11.1	0.0276	0.1685	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0035	0.0092	0.0815
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0092	0.0815
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (small chain)	0.0036	0.0102	0.0213
Schistosoma mansoni	RAR-like nuclear receptor	0.0035	0.0092	0.0548
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0022	0.0009	0.0019
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.1539	1	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0304	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0193	0.1133	1
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0022	0.0009	0.0019
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0022	0.0009	0.0009
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0022	0.0009	0.0009
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.0039	0.0122	0.0726
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0022	0.0009	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0035	0.0092	0.0548
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0035	0.0092	0.0548
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0035	0.0092	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Mycobacterium ulcerans	succinate-semialdehyde dehydrogenase	0.0039	0.0122	0.0122
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0119	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0726
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0035	0.0092	0.0548
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0067	0.0304	0.1807
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0189	0.1108	0.6579
Loa Loa (eye worm)	glutaminase 2	0.0276	0.1685	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0035	0.0092	0.0548
Echinococcus multilocularis	ecdysone induced protein 78C	0.0035	0.0092	0.0815
Treponema pallidum	quinoline 2-oxidoreductase	0.003	0.0062	0.0062
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0035	0.0092	0.0815
Brugia malayi	nuclear receptor NHR-88	0.0035	0.0092	0.0548
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0022	0.0009	0.0009
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0143	0.0805	0.7104
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.1539	1	1
Schistosoma mansoni	glutaminase	0.0276	0.1685	1
Schistosoma mansoni	thyroid hormone receptor	0.0035	0.0092	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0726
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0304	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0125	0.0685	0.6044
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0035	0.0092	0.0548
Loa Loa (eye worm)	steroid hormone receptor	0.0035	0.0092	0.0548
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.1539	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0035	0.0092	0.0815
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0022	0.0009	0.0009
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0022	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0189	0.1108	0.6579
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0119	0.1054
Plasmodium vivax	ornithine aminotransferase, putative	0.0022	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Echinococcus multilocularis	Aminotransferase class III	0.0022	0.0009	0.0079
Brugia malayi	ecdysteroid receptor	0.0035	0.0092	0.0548
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0022	0.0009	0.0053
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0092	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0092	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0035	0.0092	0.0548
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0035	0.0092	0.0548
Mycobacterium ulcerans	L-lysine aminotransferase	0.0245	0.1479	0.1479
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0035	0.0092	0.0815
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0067	0.0304	0.2687
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0035	0.0092	0.0548
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0235	0.1413	0.8391
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0035	0.0092	0.0548
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0022	0.0009	0.0019
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0064	0.0285	0.0285
Mycobacterium ulcerans	NAD-dependent aldehyde dehydrogenase AldA	0.0039	0.0122	0.0122
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0064	0.0285	0.0285
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0035	0.0092	0.0548
Mycobacterium ulcerans	glutaminase	0.0276	0.1685	0.1685
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0	0.5
Echinococcus granulosus	Aminotransferase class III	0.0022	0.0009	0.0079
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0067	0.0067
Onchocerca volvulus	Protein ultraspiracle homolog	0.0035	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.1539	1	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0067	0.0304	0.2687
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0035	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0092	0.0548
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0092	0.0548
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0092	0.0548
Toxoplasma gondii	NADP-dependent succinate-semialdehyde dehydrogenase	0.0039	0.0122	0.0122
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0089	0.0451	0.0939
Brugia malayi	Succinate semialdehyde dehydrogenase, mitochondrial precursor	0.0039	0.0122	0.0726
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0035	0.0092	0.0548
Onchocerca volvulus		0.0035	0.0092	0.5
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.1539	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0092	0.0548
Schistosoma mansoni	aldehyde dehydrogenase	0.0193	0.1133	0.6726
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0304	1
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0064	0.0285	0.0593
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0125	0.0689	0.0689
Trichomonas vaginalis	glutaminase, putative	0.0276	0.1685	1
Brugia malayi	nuclear hormone receptor	0.0035	0.0092	0.0548
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0036	0.0102	0.0102
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0039	0.0122	0.4019
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0036	0.0102	0.0102

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.205 uM	Inhibition of recombinant Mycobacterium tuberculosis Dxr expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells using DOXP as substrate assessed as NADPH oxidation by spectrophotometric analysis	ChEMBL.	25781377
IC50 (binding)	= 7.13 uM	Inhibition of recombinant Escherichia coli Dxr expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells using DOXP as substrate assessed as NADPH oxidation preincubated for 5 mins with NADPH followed by substrate addition by spectrophotometric analysis	ChEMBL.	25781377
MIC50 (functional)		Antibacterial activity against Escherichia coli ATCC 8739 by two-fold broth microdilution method	ChEMBL.	25781377
MIC50 (functional)		Antibacterial activity against Escherichia coli ATCC 25922 by two-fold broth microdilution method	ChEMBL.	25781377
MIC50 (functional)		Antibacterial activity against Escherichia coli K-12 by two-fold broth microdilution method	ChEMBL.	25781377
MIC50 (functional)	= 0.74 uM	Schizontocidal activity against Plasmodium falciparum K1 infected in human RBC after 72 hrs by Malstat reagent-based spectrophotometric analysis	ChEMBL.	25781377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3422252

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1929368