Detailed information for compound 1931790

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 529.63 | Formula: C30H35N5O4
  • H donors: 3 H acceptors: 5 LogP: 4.19 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: ONC(=O)CCCCCCC(=O)N1C/C=C/CCOc2cccc(c2)c2nc(Nc3cc(C1)ccc3)ncc2
  • InChi: 1S/C30H35N5O4/c36-28(34-38)14-4-1-2-5-15-29(37)35-18-6-3-7-19-39-26-13-9-11-24(21-26)27-16-17-31-30(33-27)32-25-12-8-10-23(20-25)22-35/h3,6,8-13,16-17,20-21,38H,1-2,4-5,7,14-15,18-19,22H2,(H,34,36)(H,31,32,33)/b6-3+
  • InChiKey: IJOMTTFPAOSPTO-ZZXKWVIFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens histone deacetylase 7 References
Homo sapiens histone deacetylase 2 References
Homo sapiens histone deacetylase 6 References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens histone deacetylase 3 References
Homo sapiens histone deacetylase 10 References
Homo sapiens histone deacetylase 1 References
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References
Homo sapiens histone deacetylase 8 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0081 0.1686 0.0991
Echinococcus multilocularis histone deacetylase 3 0.0311 0.9051 0.8732
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.9051 0.5
Mycobacterium leprae probable zinc metalloprotease 0.0106 0.2515 0.5
Trypanosoma cruzi histone deacetylase 1, putative 0.0311 0.9051 0.8811
Loa Loa (eye worm) hypothetical protein 0.0106 0.2515 0.1916
Schistosoma mansoni histone deacetylase 1 2 3 0.0146 0.3784 0.3784
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.9051 0.5
Loa Loa (eye worm) hypothetical protein 0.0106 0.2515 0.1916
Echinococcus multilocularis histone deacetylase 7 0.0333 0.9762 0.9682
Echinococcus granulosus histone deacetylase 0.0333 0.9762 0.9682
Trypanosoma brucei histone deacetylase, putative 0.0333 0.9762 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0054 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0079 0.1627 0.0925
Loa Loa (eye worm) hypothetical protein 0.0081 0.1686 0.0991
Entamoeba histolytica histone deacetylase, putative 0.0311 0.9051 0.5
Loa Loa (eye worm) hypothetical protein 0.0187 0.509 0.4788
Loa Loa (eye worm) histone deacetylase 0.0333 0.9762 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1627 0.0925
Plasmodium falciparum histone deacetylase, putative 0.0333 0.9762 1
Toxoplasma gondii histone deacetylase HDAC4 0.0146 0.3784 0.1751
Loa Loa (eye worm) histone deacetylase 3 0.0311 0.9051 0.9207
Trypanosoma cruzi histone deacetylase 1, putative 0.0311 0.9051 0.8811
Echinococcus multilocularis histone deacetylase 8 0.0146 0.3784 0.1695
Loa Loa (eye worm) hypothetical protein 0.0146 0.3784 0.3331
Brugia malayi histone deacetylase 11 0.0146 0.3784 0.1751
Leishmania major histone deacetylase, putative 0.0333 0.9762 1
Echinococcus granulosus histone deacetylase 3 0.0311 0.9051 0.8732
Echinococcus granulosus histone deacetylase 6 0.0333 0.9762 0.9682
Trypanosoma brucei histone deacetylase 4 0.0333 0.9762 1
Echinococcus granulosus histone deacetylase 8 0.0146 0.3784 0.1695
Toxoplasma gondii histone deacetylase HDAC3 0.0311 0.9051 0.9019
Echinococcus multilocularis histone deacetylase 6 0.0341 1 1
Echinococcus multilocularis histone deacetylase 1 0.0311 0.9051 0.8732
Brugia malayi histone deacetylase 3 (HD3) 0.0311 0.9051 0.9019
Trypanosoma cruzi histone deacetylase, putative 0.0333 0.9762 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1686 0.0991
Leishmania major histone deacetylase, putative 0.0333 0.9762 1
Trypanosoma cruzi histone deacetylase, putative 0.0333 0.9762 1
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.9051 0.5
Schistosoma mansoni histone deacetylase 0.0311 0.9051 0.9051
Loa Loa (eye worm) peptidase family M13 containing protein 0.0079 0.1627 0.0925
Loa Loa (eye worm) histone deacetylase 11 0.0146 0.3784 0.3331
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 0.9051 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.9051 0.5
Trypanosoma cruzi histone deacetylase, putative 0.0333 0.9762 1
Mycobacterium ulcerans zinc metalloprotease 0.0106 0.2515 0.5
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0054 0.0829 0.0829
Plasmodium vivax histone deacetylase 1, putative 0.0311 0.9051 0.8811
Loa Loa (eye worm) hypothetical protein 0.0081 0.1686 0.0991
Schistosoma mansoni histone deacetylase 4 5 0.0333 0.9762 0.9762
Brugia malayi Histone deacetylase family protein 0.0333 0.9762 1
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0054 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0081 0.1686 0.0991
Echinococcus multilocularis histone deacetylase 0.0333 0.9762 0.9682
Schistosoma mansoni histone deacetylase 4 5 0.0333 0.9762 0.9762
Brugia malayi Histone deacetylase family protein 0.0333 0.9762 1
Brugia malayi Histone deacetylase 1 0.0311 0.9051 0.9019
Echinococcus multilocularis histone deacetylase 6 0.0333 0.9762 0.9682
Schistosoma mansoni histone deacetylase 0.0311 0.9051 0.9051
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0054 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0081 0.1686 0.0991
Giardia lamblia Histone deacetylase 0.0311 0.9051 0.5
Toxoplasma gondii histone deacetylase HDAC2 0.0311 0.9051 0.9019
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0106 0.2515 0.5
Echinococcus granulosus histone deacetylase 1 0.0311 0.9051 0.8732
Toxoplasma gondii histone deacetylase HDAC5 0.0146 0.3784 0.1751
Loa Loa (eye worm) histone deacetylase 7A 0.0333 0.9762 1
Schistosoma mansoni histone deacetylase hda2 0.0341 1 1
Trypanosoma brucei histone deacetylase 1 0.0311 0.9051 0.8811
Plasmodium vivax histone deacetylase 2, putative 0.0333 0.9762 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0106 0.2515 0.2515
Echinococcus granulosus histone deacetylase 6 0.0333 0.9762 0.9682
Plasmodium vivax histone deacetylase, putative 0.0333 0.9762 1
Brugia malayi histone deacetylase 1 (HD1) 0.0311 0.9051 0.9019
Plasmodium falciparum histone deacetylase 2 0.0333 0.9762 1
Echinococcus multilocularis histone deacetylase 6 0.0333 0.9762 0.9682
Loa Loa (eye worm) hypothetical protein 0.0079 0.1627 0.0925
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 0.9051 0.5
Schistosoma mansoni neprilysin-2 (M13 family) 0.0054 0.0829 0.0829
Toxoplasma gondii histone deacetylase HDAC1 0.0333 0.9762 1
Loa Loa (eye worm) histone deacetylase 1 0.0311 0.9051 0.9207
Onchocerca volvulus Histone deacetylase 10 homolog 0.0146 0.3784 1
Loa Loa (eye worm) hypothetical protein 0.0311 0.9051 0.9207
Loa Loa (eye worm) peptidase family M13 containing protein 0.0079 0.1627 0.0925
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311 0.9051 0.5
Schistosoma mansoni histone deacetylase hda2 0.0146 0.3784 0.3784
Loa Loa (eye worm) hypothetical protein 0.0195 0.5328 0.5054
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.9051 0.5
Loa Loa (eye worm) hypothetical protein 0.0106 0.2515 0.1916
Loa Loa (eye worm) hypothetical protein 0.0079 0.1627 0.0925
Trypanosoma brucei histone deacetylase 3 0.0333 0.9762 1
Trichomonas vaginalis histone deacetylase, putative 0.0311 0.9051 0.5
Echinococcus granulosus histone deacetylase 7 0.0333 0.9762 0.9682

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 5.89 uM Antiproliferative activity against human MV4-11 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay ChEMBL. 25800646
IC50 (binding) = 310 nM Inhibition of HDAC (unknown origin) using Fluor de Lys substrate after 2 hrs by microplate reader ChEMBL. 25800646
IC50 (binding) = 558 nM Inhibition of human recombinant JAK2 using Z'LYTETry6 peptide substrate after 1 hr by microplate reader ChEMBL. 25800646
IC50 (binding) = 1256 nM Inhibition of human recombinant FLT3 after 1 hr by LanthaScreen assay platform ChEMBL. 25800646

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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