Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain containing 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0488 | 0.1492 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.5849 | 0.7523 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0075 | 0.2327 | 0.2268 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0488 | 0.1492 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0075 | 0.2327 | 0.7109 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.3274 | 0.1233 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0075 | 0.2327 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0488 | 0.1492 |
Onchocerca volvulus | 0.0165 | 1 | 1 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0075 | 0.2327 | 0.2268 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0075 | 0.2327 | 0.2268 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0075 | 0.2327 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0488 | 0.1492 |
Echinococcus multilocularis | aminopeptidase N | 0.0165 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0075 | 0.2327 | 0.7109 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0075 | 0.2327 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.7749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3599 | 0.459 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0086 | 0.3274 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0165 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0086 | 0.3274 | 1 |
Loa Loa (eye worm) | aminopeptidase N | 0.0075 | 0.2327 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3274 | 0.4167 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0075 | 0.2327 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0075 | 0.2327 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0075 | 0.2327 | 0.5 |
Echinococcus granulosus | bromodomain containing 2 | 0.0086 | 0.3274 | 0.1233 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0075 | 0.2327 | 0.704 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0075 | 0.2327 | 0.2268 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0086 | 0.3274 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0075 | 0.2327 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.3274 | 0.1233 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0075 | 0.2327 | 0.704 |
Entamoeba histolytica | aminopeptidase, putative | 0.0075 | 0.2327 | 0.5 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0053 | 0.0488 | 0.1492 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0075 | 0.2327 | 0.2268 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0075 | 0.2327 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0075 | 0.2327 | 0.5 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0086 | 0.3274 | 0.3222 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0075 | 0.2327 | 0.2268 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.34 uM | Inhibition of BRD4(1) (unknown origin) incubated for 4 hrs by (+)-JQ1 fluorescent ligand based fluorescence anisotrophy | ChEMBL. | 25559428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.