Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1288 | 0.1288 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.1325 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.1288 | 0.9715 |
Brugia malayi | Protein kinase domain | 0.0064 | 0.1325 | 0.1325 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.1325 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.1325 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0064 | 0.1325 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.1325 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.1325 | 0.1628 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.1325 | 0.1628 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.1325 | 0.1628 |
Schistosoma mansoni | protein kinase | 0.0038 | 0.0037 | 0.0277 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.1325 | 0.1628 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.1325 | 0.1628 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0037 | 0.0277 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.1325 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0037 | 0.0277 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.1325 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.1325 | 0.1628 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0037 | 0.0277 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.8137 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0038 | 0.0037 | 0.0045 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.1325 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0064 | 0.1325 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.8137 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 27 nM | Inhibition of human recombinant PAK1 kinase domain using coumarin/fluorescein-labeled FRET peptide as substrate assessed as substrate phosphorylation at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay | ChEMBL. | 26030457 |
Ki (binding) | = 70 nM | Inhibition of recombinant human GST-tagged PAK1 kinase domain expressed in baculovirus expression system assessed as suppression of phosphorylation of coumarin/fluorescein-labelled FRET peptide substrate at Ser/Thr19 residues preincubated with substrate for 10 mins followed by enzyme addition measured after 60 mins by Z-Lyte assay | ChEMBL. | 27346791 |
Ki (binding) | = 144 nM | Inhibition of human recombinant PAK4 kinase domain using coumarin/fluorescein-labeled FRET peptide as substrate assessed as substrate phosphorylation at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay | ChEMBL. | 26030457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.