Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0015 | 0.0004 | 0.0004 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0187 | 0.761 | 0.761 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0015 | 0.0004 | 0.0004 |
Plasmodium falciparum | plasmepsin VI | 0.0063 | 0.2118 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0063 | 0.2118 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0063 | 0.2118 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0187 | 0.761 | 0.761 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0063 | 0.2118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0187 | 0.761 | 0.761 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | Pepsin A precursor | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0063 | 0.2118 | 0.2118 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5006 | 0.5006 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0063 | 0.2118 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0065 | 0.222 | 0.222 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0128 | 0.5006 | 0.5006 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0063 | 0.2118 | 0.2118 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0015 | 0.0004 | 0.0004 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0063 | 0.2118 | 0.2118 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0187 | 0.761 | 0.761 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0187 | 0.761 | 0.761 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0185 | 0.7512 | 0.7512 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0187 | 0.761 | 0.761 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0128 | 0.5006 | 0.5006 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0063 | 0.2118 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0185 | 0.7512 | 0.7512 |
Onchocerca volvulus | 0.0015 | 0.0004 | 0.5 | |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0063 | 0.2118 | 0.2118 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2118 | 0.2118 |
Plasmodium falciparum | plasmepsin I | 0.0063 | 0.2118 | 1 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0128 | 0.5006 | 0.5006 |
Plasmodium falciparum | plasmepsin IV | 0.0063 | 0.2118 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0063 | 0.2118 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0063 | 0.2135 | 0.2135 |
Onchocerca volvulus | 0.0015 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.