Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_133865 | All targets in OG5_133865 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0414 | 0.9732 | 0.9732 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0175 | 0.2884 | 0.2884 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0126 | 0.1477 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0126 | 0.1477 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0414 | 0.9732 | 0.9732 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0414 | 0.9732 | 0.9732 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0126 | 0.1477 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0175 | 0.2884 | 0.2884 |
Chlamydia trachomatis | glutamine binding protein | 0.0126 | 0.1477 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0126 | 0.1477 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0175 | 0.2884 | 0.2884 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0126 | 0.1477 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16098 nM | Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins | ChEMBL. | 26481657 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.