Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0024 | 0.4238 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0875 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.099 | 0.2336 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0011 | 0.0824 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0011 | 0.0824 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0011 | 0.0824 | 0.5 |
Echinococcus granulosus | lamin | 0.0024 | 0.4238 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0011 | 0.0824 | 0.1944 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0024 | 0.4238 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0013 | 0.1323 | 0.3123 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.4238 | 1 |
Onchocerca volvulus | 0.0024 | 0.4238 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0875 | 0.2065 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0011 | 0.0824 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0024 | 0.4238 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.4123 | 0.9729 |
Echinococcus granulosus | lamin dm0 | 0.0024 | 0.4238 | 1 |
Echinococcus multilocularis | musashi | 0.0024 | 0.4238 | 1 |
Echinococcus multilocularis | lamin | 0.0024 | 0.4238 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0011 | 0.0824 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0024 | 0.4238 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0011 | 0.0824 | 0.1944 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0013 | 0.1323 | 0.1463 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0011 | 0.0824 | 0.1944 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0024 | 0.4238 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0024 | 0.4238 | 1 |
Brugia malayi | intermediate filament protein | 0.0024 | 0.4238 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.