Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0785 | 0.0785 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Echinococcus multilocularis | neuroligin | 0.0022 | 0.0785 | 0.0785 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Schistosoma mansoni | gliotactin | 0.0022 | 0.0785 | 0.0785 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.0785 | 0.0785 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.0785 | 0.0785 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0785 | 0.0785 |
Onchocerca volvulus | 0.0022 | 0.0785 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0.0785 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0.0785 | 0.5 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Onchocerca volvulus | 0.0022 | 0.0785 | 1 | |
Onchocerca volvulus | 0.0022 | 0.0785 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0131 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.0785 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.0785 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0.0785 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Onchocerca volvulus | 0.0022 | 0.0785 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0785 | 0.0785 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Onchocerca volvulus | 0.0022 | 0.0785 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0785 | 0.0785 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0785 | 0.0785 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0.0785 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.0785 | 0.0785 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0785 | 0.0785 |
Brugia malayi | Carboxylesterase family protein | 0.0131 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0131 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Echinococcus granulosus | neuroligin | 0.0022 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0785 | 0.0785 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 71.7 nM | BindingDB_Patents: Enzymatic Assay. A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reactions were carried out in a 384-well plate (Matrical MP-101) in a 10 L total volume. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovine serum albumin (BSA), 0.0005% Tween-20, ATP (4 M for JAK2 and JAK3, 40 M for JAK1 and 7 M for Tyk2)), 2% DMSO and 1 M peptide substrate (JAKtide for JAK2 and JAK3 and IRS-1 peptide for JAK1 and Tyk2). Compounds were diluted serially in 100% dimethyl sulfoxide and tested in an 11 point dose response in duplicate or quadruplicate (200 nl of compound/DMSO was added per 10 L reaction). The reactions were initiated by the addition of enzyme to the final concentration of 2 nM JAK2, 1 nM JAK3, 12 nM Tyk2 or 20 nM JAK1. The assay was run for 240 minutes for JAK1, 150 minutes for JAK2, 90 minutes for JAK3 and 70 minutes for Tyk2. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.