Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0086 | 1 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0086 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0086 | 1 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0086 | 1 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0086 | 1 | 0.5 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0086 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus granulosus | proteasome prosome macropain | 0.0086 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0086 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 1 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0086 | 1 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0086 | 1 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 135 nM | BindingDB_Patents: Inhibition Assay. Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the solution containing 50 mM Tris-HCl (pH 7.5), 0.1 mM DTT, 0.25 mM NAD+, 10 µg of purified 15-PGDH enzyme, 21 µM PGE2 and various concentrations (0.0001 µM to 64 µM) of the derivatives according to the present invention was added to each cell. The absorbance of the reaction mixture was recorded at 340 nm so that the activities of the derivatives according to the present invention as 15-PGDH inhibitors were determined from a standard curve prepared from the absorbance of various concentrations of NADH at 340 nm. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.