Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0073 | 0.5956 | 0.8159 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0039 | 0.101 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.101 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2778 | 0.1967 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0041 | 0.1344 | 0.0372 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.5956 | 0.5 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2778 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.73 |
Leishmania major | cytochrome P450 reductase, putative | 0.0073 | 0.5956 | 0.5956 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.5987 | 0.8202 |
Treponema pallidum | flavodoxin | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0039 | 0.101 | 0.1383 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0041 | 0.1344 | 0.0372 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0083 | 0.73 | 0.73 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0083 | 0.73 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.5987 | 0.8202 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.73 | 0.7691 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0051 | 0.2778 | 0.2927 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0041 | 0.1344 | 0.0372 |
Echinococcus multilocularis | methionine synthase reductase | 0.0051 | 0.2778 | 0.1967 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.101 | 0.101 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.4469 | 0.6121 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0039 | 0.101 | 0.5 |
Leishmania major | carboxylase, putative | 0.0039 | 0.101 | 0.101 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0098 | 0.9491 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0083 | 0.73 | 0.7691 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 0.73 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0083 | 0.73 | 1 |
Leishmania major | p450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 0.73 | 1 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.5956 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0073 | 0.5956 | 0.8159 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.6997 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 1 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0098 | 0.9491 | 1 |
Brugia malayi | flavodoxin family protein | 0.0083 | 0.73 | 0.7691 |
Echinococcus granulosus | methionine synthase reductase | 0.0051 | 0.2778 | 0.1967 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.6997 |
Brugia malayi | FAD binding domain containing protein | 0.0051 | 0.2778 | 0.2927 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0083 | 0.73 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0083 | 0.73 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.101 | 0.101 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0042 | 0.1434 | 0.0472 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0083 | 0.73 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0039 | 0.101 | 0.101 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0083 | 0.73 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0039 | 0.101 | 0.1383 |
Brugia malayi | FAD binding domain containing protein | 0.0083 | 0.73 | 0.7691 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0039 | 0.101 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.