Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | flavodoxin | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.73 | 0.7691 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2778 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0083 | 0.73 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0039 | 0.101 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.101 | 0.101 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.5987 | 0.8202 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.101 | 0.101 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0083 | 0.73 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.101 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 0.73 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.6997 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0041 | 0.1344 | 0.0372 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.73 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0041 | 0.1344 | 0.0372 |
Brugia malayi | FAD binding domain containing protein | 0.0051 | 0.2778 | 0.2927 |
Leishmania major | carboxylase, putative | 0.0039 | 0.101 | 0.101 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.5956 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0083 | 0.73 | 0.7691 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0039 | 0.101 | 0.101 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.5987 | 0.8202 |
Echinococcus multilocularis | methionine synthase reductase | 0.0051 | 0.2778 | 0.1967 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0039 | 0.101 | 0.1383 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0051 | 0.2778 | 0.2927 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0039 | 0.101 | 0.5 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Trypanosoma cruzi | p450 reductase, putative | 0.0083 | 0.73 | 1 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.5956 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2778 | 0.1967 |
Echinococcus granulosus | methionine synthase reductase | 0.0051 | 0.2778 | 0.1967 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0083 | 0.73 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0083 | 0.73 | 0.7691 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0083 | 0.73 | 0.73 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0073 | 0.5956 | 0.8159 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0042 | 0.1434 | 0.0472 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.4469 | 0.6121 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.6997 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0083 | 0.73 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0083 | 0.73 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0098 | 0.9491 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0098 | 0.9491 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 1 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0039 | 0.101 | 0.1383 |
Leishmania major | cytochrome P450 reductase, putative | 0.0073 | 0.5956 | 0.5956 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 0.73 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0039 | 0.101 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0041 | 0.1344 | 0.0372 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0083 | 0.73 | 0.7691 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0073 | 0.5956 | 0.8159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.