Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Solute carrier organic anion transporter family member 2A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Putative organic anion transporter | Get druggable targets OG5_139610 | All targets in OG5_139610 |
Brugia malayi | prostaglandin transporter | Get druggable targets OG5_139610 | All targets in OG5_139610 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_139610 | All targets in OG5_139610 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.3187 | 1 |
Echinococcus multilocularis | geminin | 0.0178 | 0.3187 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.2106 | 0.2106 |
Onchocerca volvulus | Putative organic anion transporter | 0.051 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0604 | 0.0604 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.2106 | 0.2106 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0264 | 0.0828 |
Schistosoma mansoni | organic anion transporter | 0.0034 | 0.0219 | 0.0688 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.3187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0034 | 0.0219 | 0.0688 |
Onchocerca volvulus | Putative organic anion transporter | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0604 | 0.0604 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0034 | 0.0219 | 0.0219 | |
Onchocerca volvulus | 0.0034 | 0.0219 | 0.0219 | |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0034 | 0.0219 | 0.0688 |
Onchocerca volvulus | 0.0034 | 0.0219 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Echinococcus granulosus | geminin | 0.0178 | 0.3187 | 1 |
Onchocerca volvulus | 0.0034 | 0.0219 | 0.0219 | |
Schistosoma mansoni | organic anion transporter | 0.0034 | 0.0219 | 0.0688 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0034 | 0.0219 | 0.0219 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0034 | 0.0219 | 0.0688 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0604 | 0.0604 |
Trypanosoma cruzi | MFS transporter, putative | 0.0034 | 0.0219 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Onchocerca volvulus | Putative organic anion transporter | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.2106 | 0.2106 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0034 | 0.0219 | 0.0688 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0034 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0264 | 0.0264 |
Onchocerca volvulus | 0.0034 | 0.0219 | 0.0219 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0604 | 0.0604 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0219 | 0.0219 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0034 | 0.0219 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2460 nM | BindingDB_Patents: Inhibition Assay. MDCK cells stably transfected with rat PGT (Endo et al., 2002) were seeded at 15-20% confluence on 24-well plates. The day on which the cells were seeded was considered day 1. PGE2 uptake experiments were conducted on day 4. All of the PGE2 uptake experiments were conducted at room temperature. On day 4, cells were washed twice with Waymouth buffer (135 mM NaCl, 13 mM H-Hepes, 13 mM Na-Hepes, 2.5 mM CaCl2, 1.2 mM MgCl2, 0.8 mM MgSO4, 5 mM KCl, and 28 mM D-glucose). Then 200 µL of Waymouth buffer containing [3H]PGE2 (purchased from Perkin Elmer) was added to each well. At the designed time, the uptake of [3H]PGE2 was stopped by aspiration of uptake buffer; this was followed by immediate washing twice with 500 µL of chilled Waymouth buffer. Cells were then lysed with 100 µL lysis buffer containing 0.25% SDS and 0.05 N NaOH. 1.5 mL of scintillation solution was added to each well, and intracellular [3H]PGE2 was counted by MicroBeta Counter. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.