Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 8 (sodium/calcium exchanger), member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0803 | 0.0803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0022 | 0.127 | 0.1966 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0022 | 0.127 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0063 | 0.6461 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Brugia malayi | glutathione reductase | 0.0063 | 0.6461 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0063 | 0.6461 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0016 | 0.054 | 0.0836 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0022 | 0.127 | 0.1966 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0022 | 0.127 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0022 | 0.127 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0072 | 0.0072 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0063 | 0.6461 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0022 | 0.127 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0372 | 0.0372 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0022 | 0.127 | 0.1966 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0022 | 0.127 | 0.1966 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Leishmania major | trypanothione reductase | 0.0063 | 0.6461 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0022 | 0.127 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0012 | 0.0072 | 0.0072 |
Plasmodium falciparum | thioredoxin reductase | 0.0022 | 0.127 | 0.1966 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0022 | 0.127 | 0.127 |
Toxoplasma gondii | thioredoxin reductase | 0.0063 | 0.6461 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0012 | 0.0072 | 0.0112 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0091 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.0063 | 0.6461 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0022 | 0.127 | 0.1966 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0372 | 0.0372 |
Brugia malayi | Thioredoxin reductase | 0.0063 | 0.6461 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0022 | 0.127 | 0.5 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0036 | 0.3111 | 0.4815 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0063 | 0.6461 | 0.6461 |
Plasmodium vivax | glutathione reductase, putative | 0.0063 | 0.6461 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0063 | 0.6461 | 0.6461 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0166 | 0.0166 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0022 | 0.127 | 0.127 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0016 | 0.054 | 0.0836 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3111 | 0.3111 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0022 | 0.127 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0072 | 0.0072 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0063 | 0.6461 | 0.6461 |
Plasmodium falciparum | glutathione reductase | 0.0022 | 0.127 | 0.1966 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0022 | 0.127 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0372 | 0.0372 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0022 | 0.127 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0063 | 0.6461 | 0.6461 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0022 | 0.127 | 0.1966 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0.127 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0063 | 0.6461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0072 | 0.0072 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0.127 | 0.5 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0091 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0018 | 0.0803 | 0.1242 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0022 | 0.127 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0022 | 0.127 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0063 | 0.6461 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8700 nM | BindingDB_Patents: Reverse Mode Assay. The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loaded with the dye by means of the acetoxymethyl ester Fluo-4 AM (Invitrogen, F14202), which is cleaved intracellularly by esterase activity to yield the charged species of free Fluo-4. After an preincubation period with the test compound, Gramicidine (Sigma, G5002) was added. Gramicidine is an ionophor for Na+ions mediating an increase of intracellular Na+ions. Consequently, intracellular Na+ions are exchanged against extracellular Ca2+ions (Ca2+influx, reverse mode). The intracellular elevation of Ca2+ ions was detected by measuring the fluorescence of Fluo-4 at a wavelength of 520 nm by a FLIPR device.Briefly, for the reverse mode transport assay 18000 cells per well were seeded into a 96 well microplate (Corning COSTAR 3904) and incubated overnight in culture medium (1x Nut Mix F12 (Ham) (Gibco, 21765-029); 10% (v/v) fetal calf serum. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.