Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | amiloride sensitive sodium channel | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0092 | 0.722 | 0.722 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Brugia malayi | Degenerin mec-4 | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0092 | 0.722 | 1 |
Brugia malayi | Degenerin-like protein ZK770.1 in chromosome I, putative | 0.0092 | 0.722 | 0.722 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0092 | 0.722 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | degenerin unc-8 | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | amiloride sensitive cation channel acid sensing ion channel pituitary | 0.0092 | 0.722 | 1 |
Onchocerca volvulus | 0.0117 | 1 | 1 | |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Schistosoma mansoni | FMRFamide-gated Na+ channel | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0092 | 0.722 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0117 | 1 | 1 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | protein vprbp | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | acid sensing ion channel 4 pituitary | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Brugia malayi | amiloride-sensitive sodium channel alpha-subunit, putative | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0092 | 0.722 | 1 |
Brugia malayi | Degenerin-like protein C41C4.5 in chromosome II, putative | 0.0092 | 0.722 | 0.722 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | sodium channel nonvoltage gated 1 alpha | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | protein vprbp | 0.0092 | 0.722 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0092 | 0.722 | 1 |
Echinococcus multilocularis | sodium channel nonvoltage gated 1 alpha | 0.0092 | 0.722 | 1 |
Brugia malayi | Degenerin unc-8 | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.722 | 0.722 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0092 | 0.722 | 1 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0092 | 0.722 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 46 nM | Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
EC50 (functional) | = 46 nM | Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
EC50 (functional) | > 10000 nM | Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
EC50 (functional) | > 10000 nM | Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
Efficacy (functional) | < 20 % | Agonist activity determined against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
Efficacy (functional) | < 20 % | Agonist activity determined against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
Efficacy (functional) | = 75 % | Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
Efficacy (functional) | = 75 % | Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%) | ChEMBL. | 9873735 |
Ki (binding) | = 38.4 nM | Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assay | ChEMBL. | 9873735 |
Ki (binding) | = 38.4 nM | Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assay | ChEMBL. | 9873735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.