Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0039 | 0.1574 | 0.1378 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.204 | 0.1008 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.204 | 0.1874 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.204 | 0.1008 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0039 | 0.1574 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0277 | 0.5 | |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.4137 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.1574 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.9684 | 1 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0039 | 0.1574 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0277 | 0.5 | |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 0.6205 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0039 | 0.1574 | 0.1333 |
Chlamydia trachomatis | biotin carboxylase | 0.0035 | 0.1312 | 0.5 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0101 | 0.6205 | 0.6301 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0153 | 1 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0098 | 0.5943 | 0.5827 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 0.6205 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.204 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0039 | 0.1574 | 0.5 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0039 | 0.1574 | 0.1333 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.1764 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0153 | 1 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0039 | 0.1574 | 0.1333 |
Onchocerca volvulus | 0.0021 | 0.0277 | 0.5 | |
Onchocerca volvulus | 0.0021 | 0.0277 | 0.5 | |
Onchocerca volvulus | Putative nachr subunit | 0.0021 | 0.0277 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 0.6205 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.3355 | 1 |
Onchocerca volvulus | 0.0021 | 0.0277 | 0.5 | |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0039 | 0.1574 | 0.5 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 0.6205 | 1 |
Onchocerca volvulus | 0.0021 | 0.0277 | 0.5 | |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0098 | 0.5943 | 0.5827 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0039 | 0.1574 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0039 | 0.1574 | 0.5 |
Schistosoma mansoni | pyruvate carboxylase | 0.0039 | 0.1574 | 0.1333 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.1764 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0039 | 0.1574 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.1574 | 0.1741 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 0.6205 | 0.6096 |
Loa Loa (eye worm) | acetyltransferase | 0.0153 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 0.6205 | 0.6096 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.1574 | 0.1741 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.4137 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.204 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.