TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.517 | Formula: C26H28FN3O3
H donors: 1 H acceptors: 2 LogP: 4.25 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N[C@H](c1ccc(cc1)O[C@@H]1CCN(C1)c1ccnc(c1)OCc1cccc(c1)F)C
InChi: 1S/C26H28FN3O3/c1-18(29-19(2)31)21-6-8-24(9-7-21)33-25-11-13-30(16-25)23-10-12-28-26(15-23)32-17-20-4-3-5-22(27)14-20/h3-10,12,14-15,18,25H,11,13,16-17H2,1-2H3,(H,29,31)/t18-,25+/m0/s1
InChiKey: PNATVAONCPQFBX-AVRWGWEMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	acetyl-CoA carboxylase beta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania major	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma cruzi	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania braziliensis	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania donovani	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium parvum	acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania mexicana	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium hominis	acetyl-CoA carboxylase 2	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium berghei	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01946 biotin carboxylase [EC6.3.4.14], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-coA carboxylase ACC2	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01961 acetyl-CoA carboxylase [EC6.4.1.2], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei gambiense	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium yoelii	acetyl-CoA carboxylase 1 precursor-related	Get druggable targets OG5_127493	All targets in OG5_127493
Brugia malayi	Carboxyl transferase domain containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium knowlesi	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania infantum	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Candida albicans	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0074	0.5161	0.5087
Brugia malayi	Tyrosine-protein kinase abl-1	0.011	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.011	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.011	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0074	0.5161	0.5087
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TK family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase Blk	0.011	1	1
Echinococcus multilocularis		0.0074	0.5161	0.5087
Loa Loa (eye worm)	STAT protein	0.0074	0.5161	0.5087
Onchocerca volvulus		0.011	1	1
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0039	0.0475	0.0372
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0074	0.5161	0.5087
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0074	0.5161	0.5087
Trichomonas vaginalis	protein kinase atn1, putative	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.0039	0.0475	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0039	0.0475	0.0372
Echinococcus multilocularis	N chimaerin	0.0074	0.5161	0.5087
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0074	0.5161	0.5087
Brugia malayi	Sex muscle abnormal protein 5	0.0074	0.5161	0.5087
Schistosoma mansoni	tensin	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.011	1	1
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0039	0.0475	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase Src42A	0.011	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.5161	0.5087
Schistosoma mansoni	tensin	0.0074	0.5161	0.5087
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Giardia lamblia	Kinase, NEK	0.0036	0.0151	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.5161	0.5087
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.0039	0.0475	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	tyrosine protein kinase Abl	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Schistosoma mansoni	acetyl-CoA carboxylase	0.0101	0.8867	0.8849
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	tyrosine kinase	0.011	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	c src tyrosine kinase	0.011	1	1
Brugia malayi	hypothetical protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus granulosus	tensin	0.0074	0.5161	0.5087
Schistosoma mansoni	tensin-related	0.0074	0.5161	0.5087
Echinococcus granulosus	SH2 domain containing protein 7	0.0074	0.5161	0.5087
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0074	0.5161	0.5087
Schistosoma mansoni	suppressor of cytokine signaling	0.0074	0.5161	0.5087
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.011	1	1
Onchocerca volvulus		0.0074	0.5161	0.5087
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	0.0101	0.8867	0.8849
Echinococcus granulosus	tyrosine kinase	0.011	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.011	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0036	0.0151	0.5
Brugia malayi	RhoGAP domain containing protein	0.0074	0.5161	0.5087
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0039	0.0475	0.5
Entamoeba histolytica	protein kinase, putative	0.0074	0.5161	0.5087
Giardia lamblia	Kinase, NEK	0.0036	0.0151	0.5
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.0101	0.8867	0.8849
Schistosoma mansoni	hypothetical protein	0.0074	0.5161	0.5087
Schistosoma mansoni	vav2	0.0074	0.5161	0.5087
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0074	0.5161	0.5087
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Echinococcus granulosus	N chimaerin	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase Src64B	0.011	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0074	0.5161	0.5087
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trypanosoma brucei	acetyl-CoA carboxylase	0.0101	0.8867	1
Giardia lamblia	Kinase	0.0036	0.0151	0.5
Onchocerca volvulus		0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Schistosoma mansoni	tensin-related	0.0074	0.5161	0.5087
Schistosoma mansoni	adapter molecule crk	0.0074	0.5161	0.5087
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Onchocerca volvulus		0.0074	0.5161	0.5087
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0074	0.5161	0.5087
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	tensin	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	tensin	0.0074	0.5161	0.5087
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0074	0.5161	0.5087
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0074	0.5161	0.5087
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0038	0.0387	0.024
Brugia malayi	hypothetical protein	0.011	1	1
Entamoeba histolytica	protein kinase, putative	0.0038	0.0387	0.024
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.0039	0.0475	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.011	1	1
Trichomonas vaginalis	STE family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.011	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.011	1	1
Onchocerca volvulus		0.011	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0074	0.5161	0.5087
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0063	0.3703	1
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0039	0.0475	0.0329
Echinococcus multilocularis	tyrosine protein kinase Blk	0.011	1	1
Echinococcus granulosus	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase Srms	0.011	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus granulosus	growth factor receptor bound protein 2	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Entamoeba histolytica	hypothetical protein	0.0038	0.0387	0.024
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	tyrosine protein kinase Srms	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	SH2 motif	0.0074	0.5161	0.5087
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.011	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5
Schistosoma mansoni	tensin	0.0074	0.5161	0.5087
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Brugia malayi	SRC-1	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Loa Loa (eye worm)	SRC-1	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0074	0.5161	0.5087
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Leishmania major	carboxylase, putative	0.0039	0.0475	0.0372
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	SH2 motif	0.0074	0.5161	0.5087
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.011	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.5161	0.5087
Schistosoma mansoni	GTPase activating protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine kinase	0.011	1	1
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Mycobacterium ulcerans	pyruvate carboxylase	0.0039	0.0475	0.5
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Chlamydia trachomatis	biotin carboxylase	0.0035	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0074	0.5161	0.5087
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0039	0.0475	0.5
Loa Loa (eye worm)	TK protein kinase	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0036	0.0151	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.011	1	1
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0098	0.8392	0.8367
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0074	0.5161	0.5087
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.0101	0.8867	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Brugia malayi	Protein kinase domain containing protein	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0074	0.5161	0.5087
Echinococcus granulosus	SH2 motif	0.0074	0.5161	0.5087
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Onchocerca volvulus		0.011	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0074	0.5161	0.5087
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Onchocerca volvulus		0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0074	0.5161	0.5087
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0039	0.0475	0.5
Onchocerca volvulus		0.011	1	1
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0073	0.5121	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0074	0.5161	0.5087
Echinococcus multilocularis	SHC transforming protein 3	0.0074	0.5161	0.5087
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	1	1
Echinococcus granulosus	expressed conserved protein	0.0074	0.5161	0.5087
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.011	1	1
Brugia malayi	SH2 domain containing protein	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Brugia malayi	protein-tyrosine kinase	0.011	1	1
Leishmania major	acetyl-CoA carboxylase, putative	0.0101	0.8867	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5
Giardia lamblia	Protein 21.1	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	SH2 motif	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0073	0.5121	1
Brugia malayi	SH2 domain containing protein	0.0074	0.5161	0.5087
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0074	0.5161	0.5087
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0074	0.5161	0.5087
Brugia malayi	Carboxyl transferase domain containing protein	0.0098	0.8392	0.8367
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0074	0.5161	0.5087
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0039	0.0475	0.0329
Echinococcus granulosus	c src tyrosine kinase	0.011	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0039	0.0475	0.0329
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.011	1	1
Onchocerca volvulus		0.0074	0.5161	0.5087
Echinococcus granulosus	NCK adaptor protein	0.0074	0.5161	0.5087
Brugia malayi	Tensin	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0074	0.5161	0.5087
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.011	1	1
Schistosoma mansoni	hypothetical protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0074	0.5161	0.5087
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0074	0.5161	0.5087
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.0101	0.8867	1
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0039	0.0475	0.0912
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0039	0.0475	0.0329
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0074	0.5161	0.5087
Schistosoma mansoni	nck2/grb4	0.0074	0.5161	0.5087
Echinococcus granulosus	signal transduction protein lnk realted	0.0074	0.5161	0.5087
Schistosoma mansoni	signal transduction protein lnk-related	0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0074	0.5161	0.5087
Schistosoma mansoni	pyruvate carboxylase	0.0039	0.0475	0.0329
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0039	0.0475	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	CAMK family protein kinase	0.0036	0.0151	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.5161	0.5087
Onchocerca volvulus		0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Entamoeba histolytica	hypothetical protein	0.0038	0.0387	0.024
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	1	1
Echinococcus granulosus	SH2 motif	0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Toxoplasma gondii	pyruvate carboxylase	0.0039	0.0475	0.0372
Echinococcus granulosus	tyrosine protein kinase Fyn	0.011	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.011	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0074	0.5161	0.5087
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Onchocerca volvulus		0.0074	0.5161	0.5087
Echinococcus granulosus	tyrosine protein kinase shark	0.011	1	1
Schistosoma mansoni	SH2A	0.0074	0.5161	0.5087
Loa Loa (eye worm)	TK/FER protein kinase	0.011	1	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0387	0.024
Brugia malayi	SH2 domain containing protein	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.011	1	1
Onchocerca volvulus		0.011	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0036	0.0151	0.5
Schistosoma mansoni	tyrosine kinase	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.011	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.011	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0036	0.0151	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0151	0.5
Schistosoma mansoni	shc transforming protein	0.0074	0.5161	0.5087
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.0039	0.0475	0.0372
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0151	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3691153

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2003093