Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0086 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0029 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0029 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0029 | 0.1053 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0029 | 0.1053 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0029 | 0.1053 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0029 | 0.1053 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0029 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0029 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0029 | 0.1053 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0029 | 0.1053 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0029 | 0.1053 | 0.102 |
Schistosoma mansoni | multidrug resistance protein | 0.0029 | 0.1053 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0029 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0029 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0029 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance protein E | 0.0029 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0029 | 0.1053 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0029 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0029 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0029 | 0.1053 | 1 |
Leishmania major | p-glycoprotein e | 0.0029 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0029 | 0.1053 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0029 | 0.1053 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0086 | 1 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0029 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1053 | 0.102 |
Trypanosoma brucei | p-glycoprotein | 0.0029 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0029 | 0.1053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.1053 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0029 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1016 | 0.0983 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0029 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0029 | 0.1053 | 0.5 |
Leishmania major | pentamidine resistance protein 1 | 0.0029 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1053 | 0.102 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0029 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0029 | 0.1053 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0029 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0029 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0029 | 0.1053 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 65 % | In vitro inhibitory activity against human Adenosine A3 receptor at 10e-5 M | ChEMBL. | 10636237 |
Inhibition (binding) | = 65 % | In vitro inhibitory activity against human Adenosine A3 receptor at 10e-5 M | ChEMBL. | 10636237 |
Ki (functional) | = 100 nM | Displacement of [125I]-OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Ki (functional) | = 100 nM | Displacement of [125I]-OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Ki (functional) | = 300 nM | Displacement of [125I]-LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Ki (functional) | = 300 nM | Displacement of [125I]-LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.