Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0031 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0031 | 0.1053 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0031 | 0.1053 | 0.102 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.1053 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0031 | 0.1053 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0093 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.1053 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0031 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0031 | 0.1053 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0031 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0031 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0031 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0031 | 0.1053 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0031 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0031 | 0.1053 | 0.5 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0031 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0031 | 0.1053 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 1 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0031 | 0.1053 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0031 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0031 | 0.1053 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0031 | 0.1053 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0031 | 0.1053 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0031 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0031 | 0.1053 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0031 | 0.1053 | 0.5 |
Leishmania major | pentamidine resistance protein 1 | 0.0031 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1053 | 0.102 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0031 | 0.1053 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0031 | 0.1053 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0031 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0031 | 0.1053 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0031 | 0.1053 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0031 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1053 | 0.102 |
Brugia malayi | multidrug resistance related protein 1 | 0.0031 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1016 | 0.0983 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.1053 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0031 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0031 | 0.1053 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 6 % | Compound was tested in vitro for upregulation of low density lipoprotein (LDL) receptor in human hepatocytes (HepG2 cells) at a concentration 3 uM | ChEMBL. | 8765518 |
Activity (functional) | = 6 % | Compound was tested in vitro for upregulation of low density lipoprotein (LDL) receptor in human hepatocytes (HepG2 cells) at a concentration 3 uM | ChEMBL. | 8765518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.