Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1053 | 0.102 |
Brugia malayi | multidrug resistance related protein 1 | 0.0028 | 0.1053 | 0.5 |
Trypanosoma brucei | p-glycoprotein | 0.0028 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.1053 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0028 | 0.1053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1016 | 0.0983 |
Leishmania major | pentamidine resistance protein 1 | 0.0028 | 0.1053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1053 | 0.102 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0028 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0028 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.1053 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0028 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0028 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0028 | 0.1053 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0028 | 0.1053 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0084 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1053 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0028 | 0.1053 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0028 | 0.1053 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0028 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0028 | 0.1053 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0028 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0028 | 0.1053 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0028 | 0.1053 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1053 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1053 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0028 | 0.1053 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1053 | 0.5 |
Trypanosoma brucei | multidrug resistance protein E | 0.0028 | 0.1053 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0028 | 0.1053 | 1 |
Leishmania major | p-glycoprotein e | 0.0028 | 0.1053 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0084 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0028 | 0.1053 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0028 | 0.1053 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0028 | 0.1053 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0028 | 0.1053 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0028 | 0.1053 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C50 (functional) | = 0.84 uM | Concentration required for half maximum rate of enhanced [3H]-DHS (Dihydrostreptomycin) uptake in E. coli K12 (ATCC 25868)was estimated from dose-response curves | ChEMBL. | 3543366 |
Kill at C50 (ADMET) | = 93 % | Percent killing of the total E. coli K12 (ATCC 25868) cells at the C50 concentration was determined. | ChEMBL. | 3543366 |
LD90 (ADMET) | = 0.72 uM | Lethal dose required to kill 90% of the E. coli K12 (ATCC 25868) cell population | ChEMBL. | 3543366 |
Uptake at C50 (functional) | = 2.6 | Estimated rate of [3H]-DHS uptake in E. coli K12 (ATCC 25868) | ChEMBL. | 3543366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.